蠲哮片治疗哮喘的临床及实验研究

目的：评价蠲哮片对支气管哮喘病的疗效。方法：４４７例支气管哮喘病患者，临床采用双盲或单盲对照，进行疗效及安全性临床观察，并进行平喘、祛痰、抗菌、耐缺氧等药理实验和急、慢性毒性实验。结果：临床观察蠲哮片的临床控制率为３８２％，显效率为３１２％，总有效率为９３４％；对照组（用牡荆油丸）分别为１３３％，２００％，６８５％。肺功能、ＩｇＥ等检测符合临床疗效。动物实验证实蠲哮片具有平喘、祛痰、抗菌、耐缺氧作用，其ＬＤ５０为（４０４８±５１７）ｇ／ｋｇ。结论：蠲哮片是临床治疗支气管哮喘的疗效好、毒副作用低的中药制剂。

洪广祥治疗支气管哮喘持续发作的经验

吾师洪广祥教授,从事中医临床30余年,长期致力于肺系病症的临床研究,造诣颇深,经验丰富,疗效显著。现将其诊治哮喘持续发作的经验,简介于后。 1 病因病机所谓哮喘持续发作,是指哮喘症状迁延反复,甚至一日数发,应用一般解痉平喘药物,

Clinical and Experimental Studies on Treatment of Asthma with Juanxiao Tablet(蠲哮片)

Objective: To evaluate the therapeutic effect of Juanxiao Tablet (JXT) in treating asthma. Methods: Clinical observation on 447 cases of asthma was done in double- or single-blinded control method, and the therapeutic effect and safety of JXT were analysed. The effect of JXT in anti-asthma, expectorant, antisepsis, hypoxia tolerance was studied, and its acute and chronic toxicity was also examined. Results: The clinical control rate in patients treated with JXT was 38.2%, the markedly effective rate 31.2% and the total effective rate 93.4%, whereas in patients treated with Oleum Vitex Negundo, the respective rates were 13.3%, 20.0% and 68.5%. Results of pulmonary function and IgE measurement were consistent with clinical effect. Experimental study showed that JXT has the actions of anti-asthma, expectorant, antisepsis and hypoxia tolerance enhancement, with its LD50 (40.48±5.17) g/kg. Conclusion: JXT is a new Chinese herbal preparation of good effect, with less toxic-side effect for asthma treatment.