Fifty-two patients with chemotherapy comprise cisplatin, adriamycin and dacarbazine underwent antiemetic therapy form September 1994 to June 1995. The chemotherapy regimens include CAP-VDS, ACO, EP,CHOP, AMF and MFP. ...Fifty-two patients with chemotherapy comprise cisplatin, adriamycin and dacarbazine underwent antiemetic therapy form September 1994 to June 1995. The chemotherapy regimens include CAP-VDS, ACO, EP,CHOP, AMF and MFP. The dose of PDD was 60-70 mg/M2, ADR was 4050 mg/M2 and DTIC was 300 mg/M2.This study was the randomized, cross-over study, ruled out any differences between individual patients. Group A: Granisetron was given on the first day of chemotherapy, Granisetron 3 mg, Dexamethasone 10 mg i.v. at 30 minutes before chemotherapy, Group B:Ondansetron was given on the first and second days,Ondansetron 8 mg, Dexamethasone 10 mg i.v. at 30 minutes before chemo-therapy, The rates of complete control-free of vomiting were 80.8 % and 82.7% in both groups respectively at 24 hours(P>0.05), 57.7% and 53.9% respectively(M>0.05) at second day, and 67.3% and 53.9% respectively(P<0.05) at third day. No difference was observed between both groups for the result of antiemetic control in seven days, the rate of overall control are 82.7% and 80.8% respectively(P>0.05).Adverse events with both antiemetic treatments were mild(essentially headache), the percentage of headache with ondansetron was 9.5% and granisetron 7.7%, constipation with ondansetron was 80.8%and granisetron 61.5%.Constipation: Granisetron, given as one i.v. 3 mg injection before chemotherapy plus dexamethasone, and ondansetron, given intravenously 8 mg injection before chemotherapy at the first 2 days Plus dexamethasone are similar results on acute and dalayed chemotherapyinduced vomiting in patients receiving their intensely emetogenic regimen.展开更多
文摘Fifty-two patients with chemotherapy comprise cisplatin, adriamycin and dacarbazine underwent antiemetic therapy form September 1994 to June 1995. The chemotherapy regimens include CAP-VDS, ACO, EP,CHOP, AMF and MFP. The dose of PDD was 60-70 mg/M2, ADR was 4050 mg/M2 and DTIC was 300 mg/M2.This study was the randomized, cross-over study, ruled out any differences between individual patients. Group A: Granisetron was given on the first day of chemotherapy, Granisetron 3 mg, Dexamethasone 10 mg i.v. at 30 minutes before chemotherapy, Group B:Ondansetron was given on the first and second days,Ondansetron 8 mg, Dexamethasone 10 mg i.v. at 30 minutes before chemo-therapy, The rates of complete control-free of vomiting were 80.8 % and 82.7% in both groups respectively at 24 hours(P>0.05), 57.7% and 53.9% respectively(M>0.05) at second day, and 67.3% and 53.9% respectively(P<0.05) at third day. No difference was observed between both groups for the result of antiemetic control in seven days, the rate of overall control are 82.7% and 80.8% respectively(P>0.05).Adverse events with both antiemetic treatments were mild(essentially headache), the percentage of headache with ondansetron was 9.5% and granisetron 7.7%, constipation with ondansetron was 80.8%and granisetron 61.5%.Constipation: Granisetron, given as one i.v. 3 mg injection before chemotherapy plus dexamethasone, and ondansetron, given intravenously 8 mg injection before chemotherapy at the first 2 days Plus dexamethasone are similar results on acute and dalayed chemotherapyinduced vomiting in patients receiving their intensely emetogenic regimen.
