Logical resonance has been demonstrated to be present in the Fitz Hugh-Nagumo(FHN)neuron,namely,the FHN neuron can operate as a reliable logic gate within an optimal parameter window.Here we attempt to extend the resu...Logical resonance has been demonstrated to be present in the Fitz Hugh-Nagumo(FHN)neuron,namely,the FHN neuron can operate as a reliable logic gate within an optimal parameter window.Here we attempt to extend the results to the more biologically realistic Hodgkin-Huxley(HH)model of neurons.In general,biological organisms have an optimal temperature at which the biological functions are most effective.In view of this,we examine if there is an optimal range of temperature where the HH neuron can work like a specific logic gate,and how temperature influences the logical resonance.Here we use the success probability P to measure the reliability of the specific logic gate.For AND logic gate,P increases with temperature T,reaches the maximum in an optimal window of T,and eventually decreases,which indicates the occurrence of the temperature-induced logical resonance phenomenon in the HH neuron.Moreover,single and double logical resonances can be induced by altering the frequency of the modulating periodic signal under the proper temperatures,suggesting the appearance of temperature-controlled transition of logical resonance.These results provide important clues for constructing neuron-based energy-efficient new-fashioned logical devices.展开更多
Metal ions play critical roles in the interaction between deoxyribonucleic acid(DNA) and protein.The experimental research has demonstrated that the Mg^2+ ion can affect the binding between transcription factor and DN...Metal ions play critical roles in the interaction between deoxyribonucleic acid(DNA) and protein.The experimental research has demonstrated that the Mg^2+ ion can affect the binding between transcription factor and DNA.In our work,by full-atom molecular dynamic simulation, the effects of the Mg^2+ ion on the cyclic adenosine monophosphate(cAMP)response element binding protein(CREB)/cAMP response elements(CRE) complex are investigated.It is illustrated that the number of hydrogen bonds formed at the interface between protein and DNA is significantly increased when the Mg^2+ ion is added.Hence, an obvious change in the structure of the DNA is observed.Then the DNA base groove and base pair parameters are analyzed.We find that, due to the introduction of the Mg2+ ion, the DNA base major groove becomes narrower.A potential mechanism for this observation is proposed.It is confirmed that the Mg^2+ ion can enhance the stability of the DNA–protein complex.展开更多
基金This Project supported by the National Natural Science Foundation of China (Grant No.11804111)。
文摘Logical resonance has been demonstrated to be present in the Fitz Hugh-Nagumo(FHN)neuron,namely,the FHN neuron can operate as a reliable logic gate within an optimal parameter window.Here we attempt to extend the results to the more biologically realistic Hodgkin-Huxley(HH)model of neurons.In general,biological organisms have an optimal temperature at which the biological functions are most effective.In view of this,we examine if there is an optimal range of temperature where the HH neuron can work like a specific logic gate,and how temperature influences the logical resonance.Here we use the success probability P to measure the reliability of the specific logic gate.For AND logic gate,P increases with temperature T,reaches the maximum in an optimal window of T,and eventually decreases,which indicates the occurrence of the temperature-induced logical resonance phenomenon in the HH neuron.Moreover,single and double logical resonances can be induced by altering the frequency of the modulating periodic signal under the proper temperatures,suggesting the appearance of temperature-controlled transition of logical resonance.These results provide important clues for constructing neuron-based energy-efficient new-fashioned logical devices.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11705064,11675060,and 91730301)the Fundamental Research Funds for the Central Universities,China(Grant Nos.2662016QD005 and 26622018JC017)the Huazhong Agricultural University Scientific and Technological Self-Innovation Foundation Program,China(Grant No.2015RC021)
文摘Metal ions play critical roles in the interaction between deoxyribonucleic acid(DNA) and protein.The experimental research has demonstrated that the Mg^2+ ion can affect the binding between transcription factor and DNA.In our work,by full-atom molecular dynamic simulation, the effects of the Mg^2+ ion on the cyclic adenosine monophosphate(cAMP)response element binding protein(CREB)/cAMP response elements(CRE) complex are investigated.It is illustrated that the number of hydrogen bonds formed at the interface between protein and DNA is significantly increased when the Mg^2+ ion is added.Hence, an obvious change in the structure of the DNA is observed.Then the DNA base groove and base pair parameters are analyzed.We find that, due to the introduction of the Mg2+ ion, the DNA base major groove becomes narrower.A potential mechanism for this observation is proposed.It is confirmed that the Mg^2+ ion can enhance the stability of the DNA–protein complex.
