Inspired by the limitations of nanoparticles in cancer treatment caused by their low therapeutic effects and biotoxicity,biocompatible and photothermal enhanced copper oxide-decorated carbon nanospheres(CuO@CNSs)with ...Inspired by the limitations of nanoparticles in cancer treatment caused by their low therapeutic effects and biotoxicity,biocompatible and photothermal enhanced copper oxide-decorated carbon nanospheres(CuO@CNSs)with doxorubicin hydrochloride(DOX)loading were constructed.CNSs as photothermal agents were synthesized by a hydrothermal reaction.CuO was adsorbed on the surface of CNSs,which improved the photothermal conversion efficiency due to the electron transitions between C-2 p and Cu-3 d.In addition,CuO would release Cu2+ions in the tumor microenvironment,which could produce hydroxyl radical(·OH)to induce cancer cells apoptosis via Haber-Weiss and Fenton-like reactions.DOX as a chemotherapeutic agent was located on the surface of CuO@CNSs by electrostatic adsorption and released quickly in the tumor microenvironment to kill cancer cells.The CuO@CNSs-DOX nanoplatforms realized the combination therapy of photothermal therapy(PTT),chemodynamic therapy(CDT),and chemotherapy(CT),which have strong potential for cancer treatment.展开更多
The design and synthesis of multifunctional nanocarriers for efficient synergistic cancer therapy have drawn great research interests in recent years.In this work,a nanoplatform for chemo-photothermal therapy with tar...The design and synthesis of multifunctional nanocarriers for efficient synergistic cancer therapy have drawn great research interests in recent years.In this work,a nanoplatform for chemo-photothermal therapy with targeting ligand was developed.Hollow porous structured silica nanotubes(SNTs)with controllable lengths decorated with CuS nanoparticles(NPs)on the surface as photothermal agents were prepared and further conjugated with lactobionic acid groups as a cancer cell target.SNTs with average lengths of 40,55 and 150 nm were obtained and further functionalized as drug carriers.The smallest bifunctional SNTs with targeting groups show good biocompatibility and highest cellular uptake for HepG2 cells.The release of doxorubicin hydrochloride(DOX)from the SNTs was dependent on the p H of the buffer solution and 808-nm near infrared(NIR)light irradiation.The integration of photothermal therapy(PTT)of CuS NPs and chemotherapy of anticancer drug leads to a better tumor inhibition effect than the individual therapy alone in vitro and in vivo.These results demonstrate potential applications of the nanocomposites as vector for efficient chemo-photothermal therapy.展开更多
基金supported by the National Natural Science Foundation of China(51720105015,51672269,51929201,51922097,51772124 and 51872282)the Science and Technology Cooperation Project between Chinese and Australian Governments(2017YFE0132300)+4 种基金the Science and Technology Development Planning Project of Jilin Province(20170101188JC and 20180520163JH)the Key Research Program of Frontier Sciences,CAS(YZDY-SSW-JSC018)the Youth Innovation Promotion Association of CAS(2017273)the Overseas,Hong Kong&Macao Scholars Collaborated Researching Fund(21728101)the CAS-Croucher Funding Scheme for Joint Laboratories(CAS18204)。
文摘Inspired by the limitations of nanoparticles in cancer treatment caused by their low therapeutic effects and biotoxicity,biocompatible and photothermal enhanced copper oxide-decorated carbon nanospheres(CuO@CNSs)with doxorubicin hydrochloride(DOX)loading were constructed.CNSs as photothermal agents were synthesized by a hydrothermal reaction.CuO was adsorbed on the surface of CNSs,which improved the photothermal conversion efficiency due to the electron transitions between C-2 p and Cu-3 d.In addition,CuO would release Cu2+ions in the tumor microenvironment,which could produce hydroxyl radical(·OH)to induce cancer cells apoptosis via Haber-Weiss and Fenton-like reactions.DOX as a chemotherapeutic agent was located on the surface of CuO@CNSs by electrostatic adsorption and released quickly in the tumor microenvironment to kill cancer cells.The CuO@CNSs-DOX nanoplatforms realized the combination therapy of photothermal therapy(PTT),chemodynamic therapy(CDT),and chemotherapy(CT),which have strong potential for cancer treatment.
基金supported by the National Natural Science Foundation of China(NSFC,51572257,51720105015,51672269,51929201,51922097,51772124 and 51872282)the Science and Technology Cooperation Project between Chinese and Australian Governments(2017YFE0132300)+4 种基金the Key Research Program of Frontier Sciences,CAS(YZDY-SSW-JSC018)the Overseas,Hong Kong&Macao Scholars Collaborated Researching Fund(21728101)the CAS-Croucher Funding Scheme for Joint Laboratories(CAS18204)Jiangmen Innovative Research Team Program(2017)the Major Program of Basic Research and Applied Research of Guangdong Province(2017KZDXM083)。
文摘The design and synthesis of multifunctional nanocarriers for efficient synergistic cancer therapy have drawn great research interests in recent years.In this work,a nanoplatform for chemo-photothermal therapy with targeting ligand was developed.Hollow porous structured silica nanotubes(SNTs)with controllable lengths decorated with CuS nanoparticles(NPs)on the surface as photothermal agents were prepared and further conjugated with lactobionic acid groups as a cancer cell target.SNTs with average lengths of 40,55 and 150 nm were obtained and further functionalized as drug carriers.The smallest bifunctional SNTs with targeting groups show good biocompatibility and highest cellular uptake for HepG2 cells.The release of doxorubicin hydrochloride(DOX)from the SNTs was dependent on the p H of the buffer solution and 808-nm near infrared(NIR)light irradiation.The integration of photothermal therapy(PTT)of CuS NPs and chemotherapy of anticancer drug leads to a better tumor inhibition effect than the individual therapy alone in vitro and in vivo.These results demonstrate potential applications of the nanocomposites as vector for efficient chemo-photothermal therapy.
