Developing bifunctional nanoplatforms integrating advanced biological imaging with high-performance therapeutic functions is interesting for nanoscience and biomedicine.Herein,thin-layered FePS3 nanosheets modified wi...Developing bifunctional nanoplatforms integrating advanced biological imaging with high-performance therapeutic functions is interesting for nanoscience and biomedicine.Herein,thin-layered FePS3 nanosheets modified with amine polyethylene glycol(FePS3-PEG)are synthesized by ultrasonicated exfoliation of bulk Fe PS3 single crystals under Ar atmosphere and in situ chemical functionalization with amine PEG.The prepared Fe PS3-PEG nanosheets give a photothermal conversion efficiency of 22.1%under 808-nm laser and evident T1relaxation(r1=2.69(mmol L^(-1))^(-1)S^(-1))in external magnetic fields.Biologically experimental results in vitro and in vivo demonstrate that Fe PS3-PEG nanosheets have good biocompatibility and exhibit excellent photothermal therapy(PTT)effect under clear T1-weighted magnetic resonance imaging(MRI).The characteristics of Fe PS3-PEGnanosheets enable them to be a promising nanomedicine for T1-weighted MRI-guided near-infrared PTT of cancers.展开更多
基金supported by the National Key Research and Development Program of China(2017YFA0205302)the Key Grant for Special Professors in Jiangsu Province(RK030STP18001)+9 种基金the Key Research and Development Program of Jiangsu(BE2018732)the Natural Science Key Fund for Colleges and Universities in Jiangsu Province(17KJA430011)the National Postdoctoral Program for Innovative Talents(BX20190156)the Scientific Research Foundation of Nanjing University of Posts and Telecommunications(NY218150)the Training Program of the Major Research Plan of the National Natural Science Foundation of China from Nanjing University of Posts and Telecommunications(NY218158)“1311 Talents Program”of Nanjing University of Posts and Telecommunications“100 Top Talents Program”of Sun Yat-sen University(29000-18841216)“Young-Teacher Training Program”of Sun Yat-sen University(29000-31610036)Joint Funds for the Innovation of Science and Technology in Fujian Province(2017Y9111)the Natural Science Foundation of Fujian Province(2020J01613)。
文摘Developing bifunctional nanoplatforms integrating advanced biological imaging with high-performance therapeutic functions is interesting for nanoscience and biomedicine.Herein,thin-layered FePS3 nanosheets modified with amine polyethylene glycol(FePS3-PEG)are synthesized by ultrasonicated exfoliation of bulk Fe PS3 single crystals under Ar atmosphere and in situ chemical functionalization with amine PEG.The prepared Fe PS3-PEG nanosheets give a photothermal conversion efficiency of 22.1%under 808-nm laser and evident T1relaxation(r1=2.69(mmol L^(-1))^(-1)S^(-1))in external magnetic fields.Biologically experimental results in vitro and in vivo demonstrate that Fe PS3-PEG nanosheets have good biocompatibility and exhibit excellent photothermal therapy(PTT)effect under clear T1-weighted magnetic resonance imaging(MRI).The characteristics of Fe PS3-PEGnanosheets enable them to be a promising nanomedicine for T1-weighted MRI-guided near-infrared PTT of cancers.
