目的:探讨血清免疫球蛋白E(IgE)水平与钙化性主动脉瓣疾病(CAVD)的关系。方法:符合入选标准的394例患者根据超声心动图结果分为CAVD组(n=169)和非CAVD组(non-CAVD组,n=225)。采用化学发光法测定血清IgE水平,分析两组患者间血清IgE水平...目的:探讨血清免疫球蛋白E(IgE)水平与钙化性主动脉瓣疾病(CAVD)的关系。方法:符合入选标准的394例患者根据超声心动图结果分为CAVD组(n=169)和非CAVD组(non-CAVD组,n=225)。采用化学发光法测定血清IgE水平,分析两组患者间血清IgE水平的差异以及血清IgE水平与CAVD之间的关系。结果:CAVD组患者血清IgE水平显著高于non-CAVD组(113.30 IU/ml vs 63.76 IU/ml,P<0.05),多因素Logistic回归分析也提示两组间血清IgE水平的差异有统计学意义(P<0.05),且血清IgE水平与CAVD显著相关。结论:CAVD组患者血清IgE水平显著增高;血清IgE水平是提示CAVD的独立生化指标,IgE可能在CAVD的发病过程中起重要作用。展开更多
Background Elevated serum Hs-CRP level may be an independent predictor of metabolic syndrome(MS)in healthy individuals. Many elderly patients have metabolic syndrome. Therefore,we observed the clinical features of ser...Background Elevated serum Hs-CRP level may be an independent predictor of metabolic syndrome(MS)in healthy individuals. Many elderly patients have metabolic syndrome. Therefore,we observed the clinical features of serum Hs-CRP level in elderly patients with metabolic syndrome to further understand the relationship between the two. Methods A total of 210 patients were divided into two groups:metabolic syndrome(MS,n=1112)group and non-metabolic syndrome(Non-MS,n=98)group. The serum Hs-CRP level was tested by immunoturbidimetry and the clinical features of Hs-CRP were analyzed. The associations of Hs-CRP with BMI,WHR,FBG,TG,TC,LDL-C,HDL-C,SBP,DBP and Homa-IR were determined. Results Serum HsCRP level was significantly higher in the MS group than in the non-MS group(P<0.05). Besides,with the increase in the number of included factors,the level of Hs-CRP gradually increased significantly(P<0.05).Moreover,serum Hs-CRP was positively correlated with age,BMI,WHR,SBP,DBP,FPG,FIN,TG,TC,Homa-IR(r=0.38,0.49,0.33,0.36,0.31,0.34,0.43,0.37,0.18,0.34,respectively,P<0.05)and negatively correlated with HDL-C(r=-0.37,P<0.001). Conclusion Serum Hs-CRP level is associated with many factors. It is a proactively marker for cardiovascular disease risk assessment of elderly MS patients.[S Chin J Cardiol 2019;20(3):156-162]展开更多
文摘目的:探讨血清免疫球蛋白E(IgE)水平与钙化性主动脉瓣疾病(CAVD)的关系。方法:符合入选标准的394例患者根据超声心动图结果分为CAVD组(n=169)和非CAVD组(non-CAVD组,n=225)。采用化学发光法测定血清IgE水平,分析两组患者间血清IgE水平的差异以及血清IgE水平与CAVD之间的关系。结果:CAVD组患者血清IgE水平显著高于non-CAVD组(113.30 IU/ml vs 63.76 IU/ml,P<0.05),多因素Logistic回归分析也提示两组间血清IgE水平的差异有统计学意义(P<0.05),且血清IgE水平与CAVD显著相关。结论:CAVD组患者血清IgE水平显著增高;血清IgE水平是提示CAVD的独立生化指标,IgE可能在CAVD的发病过程中起重要作用。
基金supported by the grant from the Sunsine cardiovascular,Foundation of Chinese Medical Doctor Association(No.SCRFCMDA201234)
文摘Background Elevated serum Hs-CRP level may be an independent predictor of metabolic syndrome(MS)in healthy individuals. Many elderly patients have metabolic syndrome. Therefore,we observed the clinical features of serum Hs-CRP level in elderly patients with metabolic syndrome to further understand the relationship between the two. Methods A total of 210 patients were divided into two groups:metabolic syndrome(MS,n=1112)group and non-metabolic syndrome(Non-MS,n=98)group. The serum Hs-CRP level was tested by immunoturbidimetry and the clinical features of Hs-CRP were analyzed. The associations of Hs-CRP with BMI,WHR,FBG,TG,TC,LDL-C,HDL-C,SBP,DBP and Homa-IR were determined. Results Serum HsCRP level was significantly higher in the MS group than in the non-MS group(P<0.05). Besides,with the increase in the number of included factors,the level of Hs-CRP gradually increased significantly(P<0.05).Moreover,serum Hs-CRP was positively correlated with age,BMI,WHR,SBP,DBP,FPG,FIN,TG,TC,Homa-IR(r=0.38,0.49,0.33,0.36,0.31,0.34,0.43,0.37,0.18,0.34,respectively,P<0.05)and negatively correlated with HDL-C(r=-0.37,P<0.001). Conclusion Serum Hs-CRP level is associated with many factors. It is a proactively marker for cardiovascular disease risk assessment of elderly MS patients.[S Chin J Cardiol 2019;20(3):156-162]
