Multimodal therapy has been recognized as a powerful platform for the precise treatment of cancer.However,the reported multimodal therapeutic systems often involve sophisticated components and tedious fabrication proc...Multimodal therapy has been recognized as a powerful platform for the precise treatment of cancer.However,the reported multimodal therapeutic systems often involve sophisticated components and tedious fabrication procedures.As such,developing nature-inspired and easilyobtainable theranostic agents for multimodal cancer therapy remains challenging.In this work,we propose nature-inspired nanothylakoids as a multimodal theranostic agent for cancer therapy both in vitro and in vivo.Nanothylakoids extracted from spinach leaves exhibit prominent photothermal and photodynamic inactivation on 4T1 and MCF-7 cancer cells due to their outstanding photothermal conversion/photosensitization capabilities.Additionally,the peroxidase-like catalytic activity of nanothylakoids is simultaneously verified,which facilitates the oxidation of H_(2)O_(2)to the cytotoxic hydroxyl radical(·OH)and thus cause efficient cell apoptosis.Interestingly,a selective cytotoxicity of nanothylakoids on MCF-7 cancer cells is found due to their overexpression of H_(2)O_(2).In vitro and in vivo results substantiate the prominent therapeutic outcome and excellent biosafety of nanothylakoids.Nanothylakoids with photothermal/photodynamic effects and peroxidase-like catalytic activity open a new avenue for the development of nature-inspired theranostic materials,holding great promise in multimodal cancer therapeutics.展开更多
基金supported by the National Natural Science Foundation of China(22021002,22020102005,and 22022705)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16020804)。
文摘Multimodal therapy has been recognized as a powerful platform for the precise treatment of cancer.However,the reported multimodal therapeutic systems often involve sophisticated components and tedious fabrication procedures.As such,developing nature-inspired and easilyobtainable theranostic agents for multimodal cancer therapy remains challenging.In this work,we propose nature-inspired nanothylakoids as a multimodal theranostic agent for cancer therapy both in vitro and in vivo.Nanothylakoids extracted from spinach leaves exhibit prominent photothermal and photodynamic inactivation on 4T1 and MCF-7 cancer cells due to their outstanding photothermal conversion/photosensitization capabilities.Additionally,the peroxidase-like catalytic activity of nanothylakoids is simultaneously verified,which facilitates the oxidation of H_(2)O_(2)to the cytotoxic hydroxyl radical(·OH)and thus cause efficient cell apoptosis.Interestingly,a selective cytotoxicity of nanothylakoids on MCF-7 cancer cells is found due to their overexpression of H_(2)O_(2).In vitro and in vivo results substantiate the prominent therapeutic outcome and excellent biosafety of nanothylakoids.Nanothylakoids with photothermal/photodynamic effects and peroxidase-like catalytic activity open a new avenue for the development of nature-inspired theranostic materials,holding great promise in multimodal cancer therapeutics.
