Circadian rhythm is an endogenous rhythmic behavior of organisms which can be entrained by daily light–dark cycles.The timing of human sleep-cycle is regulated by endogenous circadian rhythm and homeostatic processes...Circadian rhythm is an endogenous rhythmic behavior of organisms which can be entrained by daily light–dark cycles.The timing of human sleep-cycle is regulated by endogenous circadian rhythm and homeostatic processes. Light exposure affects both sleep timing and circadian rhythm. Now humans can extend lighting time by turning on artificial lights and wake up time is usually triggered by alarm clocks to meet social schedules. This modern lifestyle is believed to be related with a temporal mismatch between sleep and circadian rhythmicity(social jet-lag) and insufficient sleep, which lead to ill mental and physical health outcomes. At present, the impacts of self-selection of light exposure and social constrains on sleep timing is far from clear. According to preferred sleep-wake schedule, there are three different chronotypes. In this paper, we apply a mathematical model to get a quantitative comparison of sleep timing of people with different chronotypes with the effects of modern light consumption and social constrains. The results show that the prolonged day light and evening light exposure both delay preferred sleep timing with the sleep duration almost unchanged. People of evening-type or with longer intrinsic periods are most expected to be vulnerable to evening light. Increasing light exposure can offset the effect of evening light to some extent, but it is most difficult for evening-type people. Social constrains cause the largest social jet-lag in people of evening-type, which increases with evening light intensity or intrinsic periods. Morning-type people's sleep symptoms worsens, while that of evening-type people improves with age. This study provides a theoretical reference for preventing and treating sleep disorder and social jet-lag for individuals with different chronotypes.展开更多
基金Project supported by the National Natural Science Foundation of China (Grant No. 11672177)。
文摘Circadian rhythm is an endogenous rhythmic behavior of organisms which can be entrained by daily light–dark cycles.The timing of human sleep-cycle is regulated by endogenous circadian rhythm and homeostatic processes. Light exposure affects both sleep timing and circadian rhythm. Now humans can extend lighting time by turning on artificial lights and wake up time is usually triggered by alarm clocks to meet social schedules. This modern lifestyle is believed to be related with a temporal mismatch between sleep and circadian rhythmicity(social jet-lag) and insufficient sleep, which lead to ill mental and physical health outcomes. At present, the impacts of self-selection of light exposure and social constrains on sleep timing is far from clear. According to preferred sleep-wake schedule, there are three different chronotypes. In this paper, we apply a mathematical model to get a quantitative comparison of sleep timing of people with different chronotypes with the effects of modern light consumption and social constrains. The results show that the prolonged day light and evening light exposure both delay preferred sleep timing with the sleep duration almost unchanged. People of evening-type or with longer intrinsic periods are most expected to be vulnerable to evening light. Increasing light exposure can offset the effect of evening light to some extent, but it is most difficult for evening-type people. Social constrains cause the largest social jet-lag in people of evening-type, which increases with evening light intensity or intrinsic periods. Morning-type people's sleep symptoms worsens, while that of evening-type people improves with age. This study provides a theoretical reference for preventing and treating sleep disorder and social jet-lag for individuals with different chronotypes.
