Baroreflex plays a significant role in modulating blood pressure for the human body.It is known that activation of the vagal nerve related to baroreflex can lead to reductions of blood pressure.However,how the vagal a...Baroreflex plays a significant role in modulating blood pressure for the human body.It is known that activation of the vagal nerve related to baroreflex can lead to reductions of blood pressure.However,how the vagal activities quantitatively relate with blood pressure can hardly be achieved.Here fine carbon nanotube yarn(CNTy)electrodes were adopted for recording intrafascicular vagal activities,synchronized with measurement of arterial blood pressure in a rat.Together with a novel algorithm,the results preliminarily quantified that there were six clusters of neural spikes within recorded vagal activities,and the number of individual vagal spikes correspondingly varied with blood pressure.Especially for Cluster 2,the neural activations decreased with arterial blood pressure increasing.This study can shed lights on the quantified neural mechanism underlying the control of vagal activities on blood pressure,and guide the vagal-nerve neuromodulation for treating hypertension.展开更多
The vagus nerve carries sensory information from multiple organs in the body.The recording of its activity and further processing is a key step for neuromodulation treatments.This paper presents a specific algorithm f...The vagus nerve carries sensory information from multiple organs in the body.The recording of its activity and further processing is a key step for neuromodulation treatments.This paper presents a specific algorithm for the processing and discrimination of intrafascicular recordings from the vagus nerve using the novel carbon nanotube yarn electrodes.Up to four different neural waveforms were found,whose occurrence corresponded to distinct levels of anesthesia depth.展开更多
基金the Innovation Studio from School of Biomedical Engineering,Shanghai Jiao Tong University,and the Medical-Engineering Cross Project of Shanghai Jiao Tong University(No.YG2017MS53)。
文摘Baroreflex plays a significant role in modulating blood pressure for the human body.It is known that activation of the vagal nerve related to baroreflex can lead to reductions of blood pressure.However,how the vagal activities quantitatively relate with blood pressure can hardly be achieved.Here fine carbon nanotube yarn(CNTy)electrodes were adopted for recording intrafascicular vagal activities,synchronized with measurement of arterial blood pressure in a rat.Together with a novel algorithm,the results preliminarily quantified that there were six clusters of neural spikes within recorded vagal activities,and the number of individual vagal spikes correspondingly varied with blood pressure.Especially for Cluster 2,the neural activations decreased with arterial blood pressure increasing.This study can shed lights on the quantified neural mechanism underlying the control of vagal activities on blood pressure,and guide the vagal-nerve neuromodulation for treating hypertension.
基金the National Natural Science Founda-tion of China(No.81671801)the Medical-Engineering Cross Project of Shanghai Jiao Tong University(No.YG2017MS53)the Innovation Studio from School of Biomedical Engineering,Shanghai Jiao Tong University。
文摘The vagus nerve carries sensory information from multiple organs in the body.The recording of its activity and further processing is a key step for neuromodulation treatments.This paper presents a specific algorithm for the processing and discrimination of intrafascicular recordings from the vagus nerve using the novel carbon nanotube yarn electrodes.Up to four different neural waveforms were found,whose occurrence corresponded to distinct levels of anesthesia depth.
