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白细胞介素1β、白细胞介素6、肿瘤坏死因子α在肝癌大鼠模型肝硬化期的变化 被引量:2
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作者 阿地里江.阿布力米提 雅森.米吉提 +2 位作者 热孜万古丽.艾合买提 玉苏甫.吐尔逊 艾来提.米吉提 《新疆医科大学学报》 CAS 2011年第12期1359-1361,1365,共4页
目的探讨免疫细胞因子白细胞介素1β(IL-1β)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)在肝癌大鼠模型肝硬化期的变化及作用。方法选取雄性Wistar大鼠70只,随机分为两组,正常组(35只):饮用灭菌食用水;实验组(35只):饮用灭菌食用水... 目的探讨免疫细胞因子白细胞介素1β(IL-1β)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)在肝癌大鼠模型肝硬化期的变化及作用。方法选取雄性Wistar大鼠70只,随机分为两组,正常组(35只):饮用灭菌食用水;实验组(35只):饮用灭菌食用水配制浓度0.1mg/mL的二乙基亚硝胺(DEN)溶液,分别于第5、7、9、11w检测两组大鼠外周血IL-1β、IL-6和TNF-α等免疫指标的变化。结果与正常组相比,实验组大鼠血清IL-1β、IL-6和TNF-α水平均升高,差异均具有统计学意义(P<0.01)。结论肝癌大鼠模型肝硬化期免疫细胞因子IL-1β、IL-6和TNF-α的异常变化可促进肝硬化进一步发展为肝癌。 展开更多
关键词 二乙基亚硝胺 肝硬化 动物模型 免疫
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大鼠溃疡性结肠炎模型结肠组织的代谢组学研究 被引量:7
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作者 雅森.米吉提 阿地里江.阿布力米提 +1 位作者 库热西.玉努斯 巴图尔.买买提明 《新疆医科大学学报》 CAS 2011年第12期1350-1354,共5页
目的应用代谢组学研究技术测试与比较正常对照组和大鼠溃疡性结肠炎模型(Ulcerative ColitisModel,UCM)组结肠组织代谢产物,探讨UCM结肠组织中UC相关的特异性分子标志物。方法将Wistar大鼠随机分为正常对照组(22只)和溃疡性结肠炎模型组... 目的应用代谢组学研究技术测试与比较正常对照组和大鼠溃疡性结肠炎模型(Ulcerative ColitisModel,UCM)组结肠组织代谢产物,探讨UCM结肠组织中UC相关的特异性分子标志物。方法将Wistar大鼠随机分为正常对照组(22只)和溃疡性结肠炎模型组(21只),分笼喂养,采用2,4-二硝基氯苯(2,4-dinitrochloro-benzene,DNCB)复合乙酸法复制大鼠溃疡性结肠炎动物模型,收集两组大鼠结肠组织,进行1H-NMR图谱测定和主成分分析。结果与正常对照组大鼠相比,UC模型组结肠组织的内源性代谢谱、肠组织的代谢表型发生了显著变化,UC模型组大鼠结肠组织中丙酸、乳酸、牛磺酸、乙酸、脯氨酸、丙氨酸等小分子代谢物含量明显增加,差异有统计学意义(P<0.05)。结论 UC大鼠结肠组织的代谢谱明显偏离正常大鼠结肠组织,乳酸、牛磺酸、脯氨酸、丙氨酸等6种代谢物在临床上可作为溃疡性结肠炎早期诊疗的分子标志物。 展开更多
关键词 溃疡性结肠炎 代谢组学 分子标志物
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Abnormal Savda Syndrome:Long-Term Consequences of Emotional and Physical Stress on Endocrine and Immune Activities in An Animal Model 被引量:6
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作者 阿地里江.阿布力米提 Harald Khnel +1 位作者 Alois Strasser 哈木拉提.吾甫 《Chinese Journal of Integrative Medicine》 SCIE CAS 2013年第8期603-609,共7页
Objective: To investigate the relationship between emotional status, cold-dry environment and long-term immune responses to the stressors, and the potential pathological mechanisms between causative factors of abnorm... Objective: To investigate the relationship between emotional status, cold-dry environment and long-term immune responses to the stressors, and the potential pathological mechanisms between causative factors of abnormal Savda syndrome (ASS) and the susceptibility to disease; thus to clarify the ASS, and secondly to identify the optimal ASS animal model for further studies on traditional Uighur therapeutical formulations. Methods: Sixty mice were randomly and equally divided into 4 groups: control and 3 stress groups. The cold-dry environment was applied by keeping the mice in a climatic chamber. The emotional stress was induced by the application of the repeated electric foot-shocks in the electric foot-shock apparatus. The mice of the combined stress group underwent the repeated electric foot-shock treatment before being housed in the climatic chamber. The experimental routine was repeated for 21 days. In order to look into endocrine and immune stress responses, ELISA was used to determine the serum levels of the hormones corticotropin- releasing hormone (CRH), adrenocorticotropic hormone (ACTH), Beta-endorphin (13-END) and corticosterone (CORT), of the cytokines interleukin 2 (IL-2), interleukin 6 (IL-6), interferon-gamma (INF- ~/) and tumor necrosis factor-alpha (TNF-or), and of the immunoglobulins immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG). Lymphocyte subsets were analyzed in duplicate in order to determine differences in the T cell ratio. Results: In the cold-dry environment group, the serum levels of CRH, ACTH and CORT were significantly higher than those of the control group, whereas serum 13 -END was not found significantly different. In both the repeated electric foot-shock group as well as in the combined stress group the serum levels of CRH, ACTH, 13 -END and CORT were significantly higher. Compared to the control animals, the serum concentration of INF-,y was significantly lower in all three different stress groups. The serum level of IL-2 was decreased in the combined stress group whereas the serum TNF-~x level was significantly higher. The serum IgG level was significantly higher in all three stress groups, whereas the IgA level was lower in both chronic electric foot-shock group and combined stress group. The IgM level was found significantly higher in the combined stress group only. The percentage of CD4+ cells in peripheral blood was dramatically decreased in mice exposed to cold- dry environment, chronic electric foot-shock and combined stress, whereas the percentage of the CD8* subset was not significantly different. The CD4*/CD8~ ratios were markedly lower in both cold-dry environment group and combined stress group. (Conclusions: Combined stress can cause hyperactivity of the HPA axis, and an imbalance in the Thl/Th2 cell subset may contribute to illustrate the partial pathological mechanisms of ASS. This study identified this animal model of a combination of physical and emotional stress as an optimal model for further studies on ASS and relative therapies. 展开更多
关键词 abnormal Savda syndrome endocrine and immune activites traditional uighur medicine
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