Most elderly individuals experience cognitive decline with increasing age[1],some even suffer from pathological cognitive aging,such as dementia;however,there are exceptional elderly individuals who maintain superior ...Most elderly individuals experience cognitive decline with increasing age[1],some even suffer from pathological cognitive aging,such as dementia;however,there are exceptional elderly individuals who maintain superior cognitive performance,and they are referred to as those who have experienced successful cognitive aging(SCA)[2].The majority of research has been on pathological cognitive aging and its neural mechanisms,and much less is known about SCA[3].How is SCA characterized neuroanatomically?Specifically,whether SCA individuals’better cognitive maintenance is related to lessening pathological damage to the brain or to the higher preservation of specific brain characteristics that are not related to pathology?The neural mechanisms causing this wide array of individual cognitive differences in aging are largely unknown.展开更多
基金supported by Science and Technology Innovation2030 Major Projects(2022ZD0211600)State Key Program of National Natural Science Foundation of China(82130118)+2 种基金International Cooperation and Exchange of the National Natural Science Foundation of China(81820108034)General Program of National Natural Science Foundation of China(31971038 and 32171085)China Postdoctoral Science Foundation(2021M700485).
文摘Most elderly individuals experience cognitive decline with increasing age[1],some even suffer from pathological cognitive aging,such as dementia;however,there are exceptional elderly individuals who maintain superior cognitive performance,and they are referred to as those who have experienced successful cognitive aging(SCA)[2].The majority of research has been on pathological cognitive aging and its neural mechanisms,and much less is known about SCA[3].How is SCA characterized neuroanatomically?Specifically,whether SCA individuals’better cognitive maintenance is related to lessening pathological damage to the brain or to the higher preservation of specific brain characteristics that are not related to pathology?The neural mechanisms causing this wide array of individual cognitive differences in aging are largely unknown.