Metabolites play important roles in numerous cell biology processes,such as cell proliferation,differentiation,stress response,and cell death[1].Recently,lactate and lactate-derived lysine residue lactylation(Kla)have...Metabolites play important roles in numerous cell biology processes,such as cell proliferation,differentiation,stress response,and cell death[1].Recently,lactate and lactate-derived lysine residue lactylation(Kla)have emerged as newly discovered epigenetic modifications that play critical roles in various physiological and pathological processes.In the history of lactate research,we can categorize the studies into three mile stones(Fig.S1 online).展开更多
Pluripotent stem cells hold tremendous promise for regenerative medicine.The mechanisms underlying the acquisition and loss of pluripotency have been revealed at multiple levels.Subcellular mechanisms such as metaboli...Pluripotent stem cells hold tremendous promise for regenerative medicine.The mechanisms underlying the acquisition and loss of pluripotency have been revealed at multiple levels.Subcellular mechanisms such as metabolic and organelle remodeling are emerging as critical for pluripotent cell fate transitions.Understanding the rules and roles of organelle remodeling will not only provide important insights into pluripotency regulation,but also help improving application in regenerative medicine.In this review,we summarize recent discoveries in organelle remodeling during the acquisition and loss of pluripotency and discuss how membrane lipids orchestrate organelle remodeling and drive nuclear gene expression.展开更多
基金supported by the National Natural Science Foundation of China(92157202,32025010,32241002,92254301,32261160376,31970709,32070729,32100619,32170747,32322022,32370782,32371007,32300608,and 32300620)the National Key Research and Development Program of China(2022YFA1103800,2022YFE0210100,and 2019YFA0904500)+9 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(CAS)(XDB0480000)the Key Research Program,CAS(ZDBS-ZRKJZ-TLC003)the International Cooperation Program,CAS(154144KYSB20200006)the CAS Project for Young Scientists in Basic Research(YSBR-075)the Guangdong Provincial Science and Technology Program(2023B1111050005,2023A1515030231,2022A1515110493,2020B1212060052,2021A1515012513,2021B1515020096,2022A1515012616,and 2022A1515110951)the Guangzhou Science and Technology Program(202102021037,202102020827,202102080066,and 202206060002)the Open Research Program of Key Laboratory of Regenerative Biology,CAS(KLRB202106,KLRB202107,and KLRB202203)the CAS Youth Innovation Promotion Association(Y2021097 and 2021355)NSFC/RGC Joint Grant Scheme(N_CUHK 428/22)the Open Research Funds from the Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan People’s Hospital(202301-203)。
文摘Metabolites play important roles in numerous cell biology processes,such as cell proliferation,differentiation,stress response,and cell death[1].Recently,lactate and lactate-derived lysine residue lactylation(Kla)have emerged as newly discovered epigenetic modifications that play critical roles in various physiological and pathological processes.In the history of lactate research,we can categorize the studies into three mile stones(Fig.S1 online).
基金supported by the National Key Research and Development Program of China(2018YFA0107100)the National Natural Science Foundation of China(Grant Nos.31622037and 31631163001).
文摘Pluripotent stem cells hold tremendous promise for regenerative medicine.The mechanisms underlying the acquisition and loss of pluripotency have been revealed at multiple levels.Subcellular mechanisms such as metabolic and organelle remodeling are emerging as critical for pluripotent cell fate transitions.Understanding the rules and roles of organelle remodeling will not only provide important insights into pluripotency regulation,but also help improving application in regenerative medicine.In this review,we summarize recent discoveries in organelle remodeling during the acquisition and loss of pluripotency and discuss how membrane lipids orchestrate organelle remodeling and drive nuclear gene expression.
