Enantiopure aliphatic amines are common chiral synthons and catalysts for the asymmetric synthesis of natural products,pharmaceutical agents,agrochemicals,and functional materials[1].Therefore,the development of gener...Enantiopure aliphatic amines are common chiral synthons and catalysts for the asymmetric synthesis of natural products,pharmaceutical agents,agrochemicals,and functional materials[1].Therefore,the development of general,straightforward,and practical methodologies to access enantioenriched aliphatic amines under mild reaction conditions is a long-pursued goal in organic chemistry[2,3].Among them,the N-alkylation of amines with alkyl halides(S_(N)1 and S_(N)2),which was discovered by Hofmann in 1850,is the most straightforward and widely applied approach to construct C(sp^(3))AN bonds due to the readily available starting materials[4](Scheme 1a).Although investigated for more than 150 years,its asymmetric version has been early areas of endeavor with the only modest success,which largely relied on the use of enantioenriched alkyl halides.展开更多
基金supported by the National Natural Science Foundation of China(22101192 and 22225106).
文摘Enantiopure aliphatic amines are common chiral synthons and catalysts for the asymmetric synthesis of natural products,pharmaceutical agents,agrochemicals,and functional materials[1].Therefore,the development of general,straightforward,and practical methodologies to access enantioenriched aliphatic amines under mild reaction conditions is a long-pursued goal in organic chemistry[2,3].Among them,the N-alkylation of amines with alkyl halides(S_(N)1 and S_(N)2),which was discovered by Hofmann in 1850,is the most straightforward and widely applied approach to construct C(sp^(3))AN bonds due to the readily available starting materials[4](Scheme 1a).Although investigated for more than 150 years,its asymmetric version has been early areas of endeavor with the only modest success,which largely relied on the use of enantioenriched alkyl halides.