10号染色体上缺失的磷酸酶及张力蛋白同源基因(phosphatase and tensin homolog deleted on chro-mosome ten,PTEN)是迄今首个被发现的具有双特异性磷酸酶活性的抑癌基因,目前被认为是评价肿瘤预后的重要生物学行为指标[1],PTEN的突变...10号染色体上缺失的磷酸酶及张力蛋白同源基因(phosphatase and tensin homolog deleted on chro-mosome ten,PTEN)是迄今首个被发现的具有双特异性磷酸酶活性的抑癌基因,目前被认为是评价肿瘤预后的重要生物学行为指标[1],PTEN的突变或缺失与消化道、前列腺、脑组织等多种肿瘤的增殖、存活、基因稳定性、侵袭和转移等密切相关[2-3]。PTEN作用机制的研究,对肿瘤的诊断、预后评估及基因治疗有着重大意义,成为目前的研究热点之一[4]。研究发现,PTEN去甲基化和再表达,可抑制胃癌细胞生长和转移[5]。因此,以PTEN为靶点可能是今后治疗胃癌的新方法。本研究通过观察胃癌组织PTEN的表达,分析其与胃癌生物学的关系,报道如下。展开更多
The aim of this work is to establish volcanic seismic reflection configuration models in the rift basins of Northeast China from a new perspective,the volcanostratigraphic structure.Accordingly,the volcanostratigraphi...The aim of this work is to establish volcanic seismic reflection configuration models in the rift basins of Northeast China from a new perspective,the volcanostratigraphic structure.Accordingly,the volcanostratigraphic structure of an outcrop near the Hailaier Rift Basin was analyzed to understand the characteristics and causal factors of physical boundaries.Further,3D seismic reflection data and analysis of deep boreholes in the Songliao Rift Basin were used to establish the relationship between volcanic seismic reflection configurations and volcanostratigraphic structures.These studies suggested that in volcanic successions,physical boundaries coincide with volcanic boundaries,and their distributions are controlled by the stacking patterns of volcanic units.Therefore,volcanic seismic reflection configurations can be interpreted in terms of the stacking patterns of volcanic units.These are also referred to as general bedding patterns in volcanostratigraphy.Furthermore,four typical seismic reflection configurations were identified,namely,the chaotic,the parallel continuous,the hummocky,the multi-mound superimposed and the composite.The corresponding interpretation models comprised single massive unit,vertical,intersectional,lateral multi-mound,and composite stacking patterns.The hummocky and composite reflection configurations with intersectional and composite stacking patterns are the most favorable for the exploration of volcanic reservoirs in rift basins.展开更多
文摘10号染色体上缺失的磷酸酶及张力蛋白同源基因(phosphatase and tensin homolog deleted on chro-mosome ten,PTEN)是迄今首个被发现的具有双特异性磷酸酶活性的抑癌基因,目前被认为是评价肿瘤预后的重要生物学行为指标[1],PTEN的突变或缺失与消化道、前列腺、脑组织等多种肿瘤的增殖、存活、基因稳定性、侵袭和转移等密切相关[2-3]。PTEN作用机制的研究,对肿瘤的诊断、预后评估及基因治疗有着重大意义,成为目前的研究热点之一[4]。研究发现,PTEN去甲基化和再表达,可抑制胃癌细胞生长和转移[5]。因此,以PTEN为靶点可能是今后治疗胃癌的新方法。本研究通过观察胃癌组织PTEN的表达,分析其与胃癌生物学的关系,报道如下。
基金Projects(41472304,41430322) supported by the National Natural Science Foundation of ChinaProject(2012CB822002) supported by National Major State Basic Research Program of China
文摘The aim of this work is to establish volcanic seismic reflection configuration models in the rift basins of Northeast China from a new perspective,the volcanostratigraphic structure.Accordingly,the volcanostratigraphic structure of an outcrop near the Hailaier Rift Basin was analyzed to understand the characteristics and causal factors of physical boundaries.Further,3D seismic reflection data and analysis of deep boreholes in the Songliao Rift Basin were used to establish the relationship between volcanic seismic reflection configurations and volcanostratigraphic structures.These studies suggested that in volcanic successions,physical boundaries coincide with volcanic boundaries,and their distributions are controlled by the stacking patterns of volcanic units.Therefore,volcanic seismic reflection configurations can be interpreted in terms of the stacking patterns of volcanic units.These are also referred to as general bedding patterns in volcanostratigraphy.Furthermore,four typical seismic reflection configurations were identified,namely,the chaotic,the parallel continuous,the hummocky,the multi-mound superimposed and the composite.The corresponding interpretation models comprised single massive unit,vertical,intersectional,lateral multi-mound,and composite stacking patterns.The hummocky and composite reflection configurations with intersectional and composite stacking patterns are the most favorable for the exploration of volcanic reservoirs in rift basins.
