Objective： To investigate the correlation between trauma and pulmonary thromboembolism. Methods： Comminuted fractures and extensive soft- tissue contusion at both hind limbs were made by a falling weight from a hei...Objective： To investigate the correlation between trauma and pulmonary thromboembolism. Methods： Comminuted fractures and extensive soft- tissue contusion at both hind limbs were made by a falling weight from a height in 16 rabbits. Lung perfnsion scanning was performed to obtain the radioactivity counts before trauma, at 1 h, 48 h and 96 h after trauma. All the data were divided into 4 groups based on the above 4 time points. The rabbits were sacrificed when positive findings on the pulmonary perfnsion scanning appeared. Their lungs were harvested to be paraffln-embedded and stained with hematoxylin-erosin method for histological examination of thrombocmbolism. The randomized block design ANOVA and the method of least significant difference （LSD） were used for statistical analysis of the radioactivity counts. Results： The histological findings showed that pulmonary embolism developed in 6 of the 16 rabbits （37.5%）. Five of the 6 pulmonary embolism rabbits presented neither clinical symptoms nor positive pulmonary embolism manifestations in the lung perfnsion scanning. A significant difference was found in lung perfusion radioactivity between the pre-traumatic, post-traumatic lh groups and post-traumatic 48 b and 96 b groups （P 〈 0. 05）. Conclusions ： Fractures of the bind limbs accompanied with extensive soft-tissue contusion may cause pulmonary micro-embolism that is not sensitive to lung perfnsion scanning and tends to have no clinical symptoms. Pulmonary embofism development may take more than two days after trauma.展开更多
文摘Objective： To investigate the correlation between trauma and pulmonary thromboembolism. Methods： Comminuted fractures and extensive soft- tissue contusion at both hind limbs were made by a falling weight from a height in 16 rabbits. Lung perfnsion scanning was performed to obtain the radioactivity counts before trauma, at 1 h, 48 h and 96 h after trauma. All the data were divided into 4 groups based on the above 4 time points. The rabbits were sacrificed when positive findings on the pulmonary perfnsion scanning appeared. Their lungs were harvested to be paraffln-embedded and stained with hematoxylin-erosin method for histological examination of thrombocmbolism. The randomized block design ANOVA and the method of least significant difference （LSD） were used for statistical analysis of the radioactivity counts. Results： The histological findings showed that pulmonary embolism developed in 6 of the 16 rabbits （37.5%）. Five of the 6 pulmonary embolism rabbits presented neither clinical symptoms nor positive pulmonary embolism manifestations in the lung perfnsion scanning. A significant difference was found in lung perfusion radioactivity between the pre-traumatic, post-traumatic lh groups and post-traumatic 48 b and 96 b groups （P 〈 0. 05）. Conclusions ： Fractures of the bind limbs accompanied with extensive soft-tissue contusion may cause pulmonary micro-embolism that is not sensitive to lung perfnsion scanning and tends to have no clinical symptoms. Pulmonary embofism development may take more than two days after trauma.
