Pingyangmycin is an antitumor antibiotics developed jointly by the scientists of the Institute of Antibiotics, the Chinese Academy of Medical Sciences and North China Pharmaceutical Factory from Streptomyces verticill...Pingyangmycin is an antitumor antibiotics developed jointly by the scientists of the Institute of Antibiotics, the Chinese Academy of Medical Sciences and North China Pharmaceutical Factory from Streptomyces verticillus var. Pingyangensis. It is markedly effective against squamous cell carcinoma of the head, neck and the cervix and fairly effective against mammary, nasopharyngeal and esophageal carcinoma. Chemically it is A5 component of bleomycin. Bleomycin obtained from commercial展开更多
Ribosomes are the site for protein synthesis. However, it has not been investigated in detail whether ribosomes participate in the regulation of protein synthesis. Hummel and B(?)ck showed that depriving of streptomyc...Ribosomes are the site for protein synthesis. However, it has not been investigated in detail whether ribosomes participate in the regulation of protein synthesis. Hummel and B(?)ck showed that depriving of streptomycin resulted in unbalanced protein synthesis in Str^DA mutants: the amount of synthesis of some proteins were changed; some proteins were no longer synthesized while new proteins were produced. These results suggest that展开更多
Since Jacob and Monod proposed the operon model, a great quantity of data on the transcriptional control of gene expression have been accumulated. On the contrary, evidence for the translational control is relatively ...Since Jacob and Monod proposed the operon model, a great quantity of data on the transcriptional control of gene expression have been accumulated. On the contrary, evidence for the translational control is relatively less. Examples of this type of regulation include the expression of RNA phage genes and that of ribosomal protein genes展开更多
文摘Pingyangmycin is an antitumor antibiotics developed jointly by the scientists of the Institute of Antibiotics, the Chinese Academy of Medical Sciences and North China Pharmaceutical Factory from Streptomyces verticillus var. Pingyangensis. It is markedly effective against squamous cell carcinoma of the head, neck and the cervix and fairly effective against mammary, nasopharyngeal and esophageal carcinoma. Chemically it is A5 component of bleomycin. Bleomycin obtained from commercial
基金Projects supported by the Science Fund of Academia Sinica
文摘Ribosomes are the site for protein synthesis. However, it has not been investigated in detail whether ribosomes participate in the regulation of protein synthesis. Hummel and B(?)ck showed that depriving of streptomycin resulted in unbalanced protein synthesis in Str^DA mutants: the amount of synthesis of some proteins were changed; some proteins were no longer synthesized while new proteins were produced. These results suggest that
文摘Since Jacob and Monod proposed the operon model, a great quantity of data on the transcriptional control of gene expression have been accumulated. On the contrary, evidence for the translational control is relatively less. Examples of this type of regulation include the expression of RNA phage genes and that of ribosomal protein genes
