We eomputationally study the possible effects of thermosensitive transient receptor potential （TRP） channels on the spontaneous calcium oscillations in astrocytes at various temperatures. Based on the previous model...We eomputationally study the possible effects of thermosensitive transient receptor potential （TRP） channels on the spontaneous calcium oscillations in astrocytes at various temperatures. Based on the previous model and the result of thermosensitive TRP channels＇ open probabilities, some meaningful conclusions are obtained. It is shown that the occurrence of calcium oscillations depends on temperature and the molar heat capacity difference between the closed and open channels （ACp ）. The data indicate that calcium oscillations in astrocytes occurred in the ranges of 7℃-11 ℃ and 27℃-30℃ when/kgp is 16 kJ· mol- 1·K- 1, and ca/cium oscillations only occur in the range of 27℃-30℃ when Agp is 2kJ·mol-1·K-1. In this study, the frequency decreases rapidly at temperatures ranging from 7℃ to 11℃, and there is a contrary result in the range of 27℃-30℃.展开更多
基金Supported by the National Natural Science Foundation of China under Grant Nos 11175055 and 11547013the Natural Science Foundation of Hebei Province under Grant No A2015202268
文摘We eomputationally study the possible effects of thermosensitive transient receptor potential （TRP） channels on the spontaneous calcium oscillations in astrocytes at various temperatures. Based on the previous model and the result of thermosensitive TRP channels＇ open probabilities, some meaningful conclusions are obtained. It is shown that the occurrence of calcium oscillations depends on temperature and the molar heat capacity difference between the closed and open channels （ACp ）. The data indicate that calcium oscillations in astrocytes occurred in the ranges of 7℃-11 ℃ and 27℃-30℃ when/kgp is 16 kJ· mol- 1·K- 1, and ca/cium oscillations only occur in the range of 27℃-30℃ when Agp is 2kJ·mol-1·K-1. In this study, the frequency decreases rapidly at temperatures ranging from 7℃ to 11℃, and there is a contrary result in the range of 27℃-30℃.
