基金supported by National Natural Science Foundation of China grants(No.81773893)National Major Scientific and Technological Special Project for“Significant New Drugs Development”(No.2017ZX09301060001)+2 种基金Hubei Province Key R&D Programme(No.2020BED017 and 2020BGB004)Jiangxi Province“Thousand Talents Plan”of Scientific and Technological Innovation(No.JXSQ2019201105)Fundamental Research Funds for the Central Universities“South-Central University for Nationalities”(No.CZP20025 and No.CZP20047)