Objective To investigate the effects or magneslum metabollsm and other positive ions in pathogenesis of essential hypertension(EH) patients with insulin resistanceI1R). Methods The levels of Na+, K+, Ca2+, Mg2+ in ery...Objective To investigate the effects or magneslum metabollsm and other positive ions in pathogenesis of essential hypertension(EH) patients with insulin resistanceI1R). Methods The levels of Na+, K+, Ca2+, Mg2+ in erythrocyte and 24-hour urine samples were observed in 47 EH patients aud in 3o subjects with normal blood pressure. insulin sensitivity index was used to evaluate tke insulin sensitivity. Results in EH patients, the levels of K+ and Mg2+ in erythrocyte declined, but the levels or Na+ and Ca2+ in erythrocyte increased, and the 24-hour urinary excretion of Mg2+ reduced as compared to the subjects with normal blood pressure (P <o. o5). The levels of K+ and Mg2+ in erythrocyte of EH patients positively correlated witk insulin sensitivity index, and tke Mg2+ level in erythrocyte positively correlated with 24-hour urlnary excretion or Ca2+ and Mg2+, and tke K+ level in erythrocyte- Conclusion Abnormality or magnesium metabolism in EH patients may be the linking ractor for hypertension and insulin resistance, and may relate to inadequate intake of magnesium. Calcium and potassium may be involved in the occurrence of insulin resistance through affecting magnesium metabolism.展开更多
文摘Objective To investigate the effects or magneslum metabollsm and other positive ions in pathogenesis of essential hypertension(EH) patients with insulin resistanceI1R). Methods The levels of Na+, K+, Ca2+, Mg2+ in erythrocyte and 24-hour urine samples were observed in 47 EH patients aud in 3o subjects with normal blood pressure. insulin sensitivity index was used to evaluate tke insulin sensitivity. Results in EH patients, the levels of K+ and Mg2+ in erythrocyte declined, but the levels or Na+ and Ca2+ in erythrocyte increased, and the 24-hour urinary excretion of Mg2+ reduced as compared to the subjects with normal blood pressure (P <o. o5). The levels of K+ and Mg2+ in erythrocyte of EH patients positively correlated witk insulin sensitivity index, and tke Mg2+ level in erythrocyte positively correlated with 24-hour urlnary excretion or Ca2+ and Mg2+, and tke K+ level in erythrocyte- Conclusion Abnormality or magnesium metabolism in EH patients may be the linking ractor for hypertension and insulin resistance, and may relate to inadequate intake of magnesium. Calcium and potassium may be involved in the occurrence of insulin resistance through affecting magnesium metabolism.
