Objective To investigate the expressions of CD107a and CD107b on CD8+T lymphocytes in chronic hepatitis B(CHB)patients with different immune status.Methods Forty-three CHB patients were collected and classified accord...Objective To investigate the expressions of CD107a and CD107b on CD8+T lymphocytes in chronic hepatitis B(CHB)patients with different immune status.Methods Forty-three CHB patients were collected and classified according to the immune status(23 cases of atypical status,10 cases of immune tolerance and 10 cases of immune clearance).Another 10 cases were selected展开更多
文摘目的评价HBV DNA阳性孕妇在妊娠中晚期应用替比夫定(LDT)和替诺福韦(TDF)进行母婴阻断的疗效和安全性是否存在差异。方法在数据库CNKI、万方、维普、Pumed、CBM中检索发表于2010年1月至2019年8月的论文,收集我国学者发表的慢性HBV携带者孕妇在妊娠中晚期比较应用LDT和TDF阻断HBV母婴传播疗效的研究,采用Rev Man 5.0软件进行meta分析。结果共纳入RCT研究1篇,队列研究9篇,替比夫定组纳入孕妇897例,替诺福韦组纳入孕妇716例,新生儿出生时HBsAg阳性例数分别为11例和2例,OR=1.66,95%CI(0.76,3.62),P=0.21,新生儿出生时体重无差异OR=17.83,95%CI(-39.47,75.14),P=0.54,新生儿畸形例数分别为6例(0.67%)和1例(0.14%)。结论高载量HBV DNA慢性HBV携带者孕妇在妊娠中晚期使用LDT或TDF均能明显降低母婴传播风险,两者的母婴阻断率、不良事件发生率及胎儿畸形率均无明显差异,均安全可靠。
文摘Objective To investigate the expressions of CD107a and CD107b on CD8+T lymphocytes in chronic hepatitis B(CHB)patients with different immune status.Methods Forty-three CHB patients were collected and classified according to the immune status(23 cases of atypical status,10 cases of immune tolerance and 10 cases of immune clearance).Another 10 cases were selected