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Characterization of the Expression of CTRP9, a Paralog of Adiponectin 被引量:2
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作者 黄子纹 崔婷 +4 位作者 刘晶 庄源 孟庆航 陶李涛 李珍 《Tsinghua Science and Technology》 SCIE EI CAS 2008年第4期492-499,共8页
Adiponectin is one of the hormones secreted exclusively by the adipose tissue with anti-diabetic anti-inflammatory, anti-atherogenic, anti-atherosclerotic, and insulin-sensitizing effects. Adiponectin has structural f... Adiponectin is one of the hormones secreted exclusively by the adipose tissue with anti-diabetic anti-inflammatory, anti-atherogenic, anti-atherosclerotic, and insulin-sensitizing effects. Adiponectin has structural features including a signal peptide at the N terminus, a short variable region, a collagenous domain, and a C-terminal globular domain homologous to Clq. The family of proteins containing this globular domain is called the C1q/tumor necrosis factor-a-related proteins (CTRP). Among all the CTRPs characterized so far, the CTRP9 protein has the highest homology to adiponectin. However, little is known about the functions of CTRP9. This study examines the tissue expression of CTRP9 as well as the expression of CTRP9 during mouse development and 3T3-L1 preadipocyte differentiation. The effects of LPS, TNFα, and starvation on the expression of CTRP9 were also investigated. CTRP9 mRNA is shown to be expressed in a variety of tissues including the adipose tissues. The expression profile of CTRP9 differs from that of adiponectin, implying that they are functionally diverse although structurally homologous. 展开更多
关键词 CTRP9 ADIPONECTIN DIABETES ADIPOKINE LIPOPOLYSACCHARIDE
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