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基于阻性阳极读出方法的气体电子倍增器二维成像性能
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作者 鞠旭东 董明义 +5 位作者 周传兴 董静 赵豫斌 章红宇 祁辉荣 欧阳群 《物理学报》 SCIE EI CAS CSCD 北大核心 2017年第7期272-280,共9页
新型微结构气体探测器,如气体电子倍增器(gas electron multiplier,GEM)等,具有非常好的位置分辨率潜力(σ<100μm),但是需要匹配大规模高密度的读出电子学,给探测器的建设、造价、功耗、空间利用等带来极大压力.阻性阳极读出方法可... 新型微结构气体探测器,如气体电子倍增器(gas electron multiplier,GEM)等,具有非常好的位置分辨率潜力(σ<100μm),但是需要匹配大规模高密度的读出电子学,给探测器的建设、造价、功耗、空间利用等带来极大压力.阻性阳极读出方法可以在保持较高位置分辨率的前提下,大幅节省电子学.基于厚膜电阻工艺,一种新的阻性单元阵列结构被成功开发和应用于三级级联GEM探测器的读出阳极.该阻性阳极包括6×6个6 mm×6 mm的基本阻性单元,仅需匹配49路读出电子学.^(55)Fe放射源(5.9 keV)和X光机(8 keV)实验的结果显示探测器的位置分辨率(σ)可好于80μm,位置非线性好于1.5%.同时,探测器还获得了很好的实物成像效果.探测器的优良性能表明这种阻性阳极读出方法适用于大面积二维成像气体探测器的读出,并可用于其他探测器的读出. 展开更多
关键词 阻性阳极读出 气体电子倍增器 二维成像 位置分辨率
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加味金平饮及其改良方、清补化痰散结1号方对腺样体肥大患者的临床疗效 被引量:1
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作者 鞠旭东 游毅 +2 位作者 陈懿榕 尹贤哲 秦志仁 《中成药》 CAS CSCD 北大核心 2021年第11期3261-3264,共4页
目的评价加味金平饮及其改良方、清补化痰散结1号方对腺样体肥大患者的临床疗效。方法414例患者随机分为加味金平饮组(65例)、加味金平饮改良方组(56例)、清补化痰散结1号方组(293例),疗程8周。检测症状评分及鼻塞、张口呼吸、打鼾、呼... 目的评价加味金平饮及其改良方、清补化痰散结1号方对腺样体肥大患者的临床疗效。方法414例患者随机分为加味金平饮组(65例)、加味金平饮改良方组(56例)、清补化痰散结1号方组(293例),疗程8周。检测症状评分及鼻塞、张口呼吸、打鼾、呼吸暂停、腺样体增生改善变化。结果加味金平饮改良方组、清补化痰散结1号方组鼻塞、张口呼吸、打鼾、呼吸暂停、腺样体增生改善总有效率高于加味金平饮组(P<0.05)。治疗后,清补化痰散结1号方组症状评分降低(P<0.05),比加味金平饮改良方组、清补化痰散结1号方组更明显(P<0.05)。结论加味金平饮改良方、清补化痰散结1号方改善腺样体肥大患者临床症状、促进肥大腺样体(扁桃体)缩小的作用优于加味金平饮。 展开更多
关键词 加味金平饮 加味金平饮改良方 清补化痰散结1号方 腺样体肥大
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GEM探测器公共触发信号的优化研究
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作者 赵逸琛 董明义 +3 位作者 鞠旭东 周传兴 欧阳群 赵书俊 《核电子学与探测技术》 CAS 北大核心 2016年第6期565-569,共5页
采用模拟和实验方法研究了GEM探测器自身提供的公共触发信号的特性,得到触发信号的极性和幅度与探测器感应区的场强密切相关;通过对探测器在产生不同极性触发信号的配置高压下的好事例率、位置分辨率以及成像性能的测试分析,得出负触发... 采用模拟和实验方法研究了GEM探测器自身提供的公共触发信号的特性,得到触发信号的极性和幅度与探测器感应区的场强密切相关;通过对探测器在产生不同极性触发信号的配置高压下的好事例率、位置分辨率以及成像性能的测试分析,得出负触发信号与正触发信号一样均可以作为探测器的有效公共触发信号,不会影响探测器的性能。为GEM探测器适应不同工作条件而采用不同的公共触发高压设置提供参考。 展开更多
关键词 气体电荷放大器 公共触发信号 极性 信噪比 感应区场强
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BESⅢ主漂移室内室升级MAPS芯片探针台测试系统设计
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作者 周传兴 董明义 +2 位作者 鞠旭东 董静 欧阳群 《核电子学与探测技术》 北大核心 2017年第3期225-230,共6页
为满足北京谱仪Ⅲ主漂移室内室升级MAPS芯片测试需要,设计了一套用于芯片功能检查的芯片探针台测试系统。该系统实现了批量芯片JTAG通讯、芯片功耗、像素箝位电压、读出数据等芯片的功能检查,并可以进行芯片噪声水平以及甄别器阈值扫描... 为满足北京谱仪Ⅲ主漂移室内室升级MAPS芯片测试需要,设计了一套用于芯片功能检查的芯片探针台测试系统。该系统实现了批量芯片JTAG通讯、芯片功耗、像素箝位电压、读出数据等芯片的功能检查,并可以进行芯片噪声水平以及甄别器阈值扫描等初步测试。芯片的探针台测试不仅在非邦定的情况下完成了芯片的筛选,同时可为后续芯片在探测器上工作时的阈值等参数配置提供参考。 展开更多
关键词 单片型有源像素芯片 硅像素探测器 探针卡 芯片探针台测试
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天然化合物通过铁死亡途径抗肿瘤作用的研究进展 被引量:4
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作者 曾耀莹 吴建春 +4 位作者 骆莹滨 鞠旭东 方志红 许荣忠 李雁 《中国肿瘤》 CAS CSCD 北大核心 2021年第11期867-874,共8页
铁死亡是一种不同于凋亡、坏死、自噬的新细胞死亡方式。铁死亡的结果是有毒脂质过氧化物损伤细胞导致细胞死亡,该过程依赖铁的参与,任何影响细胞内铁离子浓度或脂质氧化代谢的因素都有可能参与铁死亡的调控。铁死亡在肿瘤治疗方面具有... 铁死亡是一种不同于凋亡、坏死、自噬的新细胞死亡方式。铁死亡的结果是有毒脂质过氧化物损伤细胞导致细胞死亡,该过程依赖铁的参与,任何影响细胞内铁离子浓度或脂质氧化代谢的因素都有可能参与铁死亡的调控。铁死亡在肿瘤治疗方面具有逆转耐药、放疗增敏、协同免疫疗法等优势。研究发现某些天然化合物具有促进铁死亡的作用,如青蒿素及其衍生物、丹参酮、荜茇酰胺等天然化合物通过铁死亡发挥抗肿瘤作用。全文就天然化合物通过铁死亡方式发挥抗肿瘤作用的进展进行综述。 展开更多
关键词 铁死亡 天然化合物 抗肿瘤作用
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Design and optimization of resistive anode for a two-dimensional imaging GEM detector
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作者 鞠旭东 董明义 +2 位作者 赵逸琛 周传兴 欧阳群 《Chinese Physics C》 SCIE CAS CSCD 2016年第8期90-95,共6页
A resistive anode for two-dimensional imaging detectors, which consists of a series of high resistivity pads surrounded by low resistivity strips, can provide good spatial resolution while reducing the number of elect... A resistive anode for two-dimensional imaging detectors, which consists of a series of high resistivity pads surrounded by low resistivity strips, can provide good spatial resolution while reducing the number of electronics channels required. The optimization of this kind of anode has been studied by both numerical simulations and experimental tests. It is found that to obtain good detector performance, the resistance ratio of the pads to the strips should be larger than 5, the nonuniformity of the pad surface resistivity should be less than 20%, a smaller pad width leads to a smaller spatial resolution, and when the pad width is 6 mm, the spatial resolution (a) can reach about 105 μm. Based on the study results, a 2-D GEM detector prototype with optimized resistive anode is constructed and a good imaging performance is achieved. 展开更多
关键词 resistive anode GEM two dimensional detector spatial resolution imaging distortion
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Aging effect in the BESIII drift chamber 被引量:1
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作者 董明义 修青磊 +9 位作者 伍灵慧 吴智 秦中华 沈品 安芬芬 鞠旭东 刘义 朱凯 欧阳群 陈元柏 《Chinese Physics C》 SCIE CAS CSCD 2016年第1期65-68,共4页
As the main tracking detector of BESIII, the drift chamber provides accurate measurements of the position and the momentum of the charged particles produced in e+e- collisions at BEPCII. After six years of operation,... As the main tracking detector of BESIII, the drift chamber provides accurate measurements of the position and the momentum of the charged particles produced in e+e- collisions at BEPCII. After six years of operation, the drift chamber is suffering from aging problems due to huge beam-related background. The gains of the cells in the first ten layers show an obvious decrease, reaching a maximum decrease of about 29% for the first layer cells. Two calculation methods for the gain change (Bhabha events and accumulated charges with 0.3% aging ratio for inner chamber cells) give almost the same results. For the Malter effect encountered by the inner drift chamber in January 2012, about 0.2% water vapor was added to the MDC gas mixture to solve this cathode aging problem. These results provide an important reference for MDC operating high voltage settings and the upgrade of the inner drift chamber. 展开更多
关键词 BESIII drift chamber hit rate AGING accumulated charges Malter effect
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Study of cluster reconstruction and track fitting algorithms for CGEM-IT at BESIII
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作者 郭玥 王亮亮 +12 位作者 鞠旭东 伍灵慧 修青磊 王海霞 董明义 胡静然 李卫东 李卫国 刘怀民 欧阳群 沈肖雁 袁野 张瑶 《Chinese Physics C》 SCIE CAS CSCD 2016年第1期92-97,共6页
Considering the effects of aging on the existing Inner Drift Chamber (IDC) of BESIII, a GEM-based inner tracker, the Cylindrical-GEM Inner Tracker (CGEM-IT), is proposed to be designed and constructed as an upgrad... Considering the effects of aging on the existing Inner Drift Chamber (IDC) of BESIII, a GEM-based inner tracker, the Cylindrical-GEM Inner Tracker (CGEM-IT), is proposed to be designed and constructed as an upgrade candidate for the IDC. This paper introduces a full simulation package for the CGEM-IT with a simplified digitization model, and describes the development of software for cluster reconstruction and track fitting, using a track fitting algorithm based on the Kalman filter method. Preliminary results for the reconstruction algorithms which are obtained using a Monte Carlo sample of single muon events in the CGEM-IT, show that the CGEM-IT has comparable momentum resolution and transverse vertex resolution to the IDC, and a better z-direction resolution than the IDC. 展开更多
关键词 BESIII CGEM-IT SIMULATION cluster reconstruction Kalman filter
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Track segment finding with CGEM-IT and matching to outer drift chamber tracks in the BESIII detector
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作者 孙新华 王亮亮 +10 位作者 伍灵慧 鞠旭东 修青磊 董燎原 董明义 李卫东 李卫国 刘怀民 欧阳群 袁野 张瑶 《Chinese Physics C》 SCIE CAS CSCD 2016年第9期125-132,共8页
The relative differences in coordinates of Cylindrical Gas Electron Multiplier Detector-based Inner Tracker(CGEM-IT) clusters are studied to search for track segments in CGEM-IT for the BESIII experiment.With the fu... The relative differences in coordinates of Cylindrical Gas Electron Multiplier Detector-based Inner Tracker(CGEM-IT) clusters are studied to search for track segments in CGEM-IT for the BESIII experiment.With the full simulation of single muon track samples, clear patterns are found and parameterized for the correct cluster combinations. The cluster combinations satisfying the patterns are selected as track segment candidates in CGEM-IT with an efficiency higher than 99%. The parameters of the track segments are obtained by a helix fitting.Some χ^2 quantities, evaluating the differences in track parameters between the track segments in CGEM-IT and the tracks found in the outer drift chamber, are calculated and used to match them. Proper χ^2 requirements are determined as a function of transverse momentum and the matching efficiency is found to be reasonable. 展开更多
关键词 CGEM-IT track segment finding track matching
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Test of a fine pitch SOI pixel detector with laser beam
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作者 刘义 卢云鹏 +1 位作者 鞠旭东 欧阳群 《Chinese Physics C》 SCIE CAS CSCD 2016年第1期98-102,共5页
A silicon pixel detector with fine pitch size of 19 μm × 19 μm, developed based on SOI (silicon-on- insulator) technology, was tested under the illumination of infrared laser pulses. As an alternative method ... A silicon pixel detector with fine pitch size of 19 μm × 19 μm, developed based on SOI (silicon-on- insulator) technology, was tested under the illumination of infrared laser pulses. As an alternative method for particle beam tests, the laser pulses were tuned to very short duration and small transverse profile to sinmlate the tracks of MIPs (minimum ionization particles) in silicon. Hit cluster sizes were measured with focused laser pulses propagating through the SOI detector perpendicular to its surface and most of the induced charge was found to be collected inside the seed pixel. For the first time, the signal amplitude as a function of the applied bias voltage was measured for this SOI detector, deepening understanding of its depletion characteristics. 展开更多
关键词 silicon pixel detector SOI infrared laser
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