基金supported by the National Natural Science Foundation of China (51602285, 51590882, 51631001, 51672010 and 81421004)the National Key R&D Program of China (2017YFA0206301)the Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and technology, Chinese Academy of Sciences (NSKF201607)