This paper was to develop a weft-knitted stent coated by a drug-loaded electro-spun fibrous membrane and then investigate its morphology, mechanical properties and in vitro drug release property. This work was started...This paper was to develop a weft-knitted stent coated by a drug-loaded electro-spun fibrous membrane and then investigate its morphology, mechanical properties and in vitro drug release property. This work was started by weft-knitting of an inner layer of such stent using polydioxanone( PDO) and silkfilament.Subsequently,5-fluorouracil( 5-FU) and curcumin( CUR) ioaded silk fibroin( SF) membranes were coated on the surface of the weftknitted stent using electro-spinning technique to endow the drug delivery function of the stent. The results show that the radial compression strength and circumferential expanding strength can reach above( 9. 1 ± 0. 4) cN/cm^2 and( 205. 0 ± 0. 2) c N/mm,respectively. The drug releasing behaviors can be sustained for 400 h. It is concluded that the stents have potential application as anintestinal stent in the future.展开更多
基金National Natural Science Foundation of China(No.51603140)Natural Science Foundation of Jiangsu Province,China(No.BK20150372)+2 种基金University Science Research Project of Jiangsu Province,China(No.16KJB540003)Key Industry Technology Innovation,Science and Technology Project of Suzhou,China(No.SYG201638)Sino-Germany Joint Project,China(No.GZ1094)
文摘This paper was to develop a weft-knitted stent coated by a drug-loaded electro-spun fibrous membrane and then investigate its morphology, mechanical properties and in vitro drug release property. This work was started by weft-knitting of an inner layer of such stent using polydioxanone( PDO) and silkfilament.Subsequently,5-fluorouracil( 5-FU) and curcumin( CUR) ioaded silk fibroin( SF) membranes were coated on the surface of the weftknitted stent using electro-spinning technique to endow the drug delivery function of the stent. The results show that the radial compression strength and circumferential expanding strength can reach above( 9. 1 ± 0. 4) cN/cm^2 and( 205. 0 ± 0. 2) c N/mm,respectively. The drug releasing behaviors can be sustained for 400 h. It is concluded that the stents have potential application as anintestinal stent in the future.
