目的探索可能影响不伴有继发性干燥综合征(sSS)的系统性红斑狼疮(SLE)患者发生干眼的细胞因子,并分析有关细胞因子的浓度与临床干眼指标之间的相关性。方法 54例诊断为SLE且符合纳入标准的患者被作为研究对象,根据患者的临床干眼指标分...目的探索可能影响不伴有继发性干燥综合征(sSS)的系统性红斑狼疮(SLE)患者发生干眼的细胞因子,并分析有关细胞因子的浓度与临床干眼指标之间的相关性。方法 54例诊断为SLE且符合纳入标准的患者被作为研究对象,根据患者的临床干眼指标分为干眼组( n =11)、干眼倾向组( n =25)、对照组( n =18)。用Western blot法检测各组患者血清中的基质金属蛋白酶2(MMP-2)及激肽释放酶13(Klk13)的含量,通过 ELISA法测量血清中的白介素1(IL-1)、 IL-6、肿瘤坏死因子α(TNF-α)的浓度。结果 MMP-2的蛋白相对表达量在干眼组与对照组之间的差异有统计学意义( P <0.05),IL-1的浓度在干眼倾向组明显高于对照组,差异有统计学意义( P <0.01),TNF-α的蛋白水平在干眼组与对照组之间的差异有统计学意义( P <0.05)。Klk13、IL-6的蛋白表达量在3组之间的差异无统计学意义( P >0.05)。结论 MMP-2、IL-1和TNF-α影响不伴有sSS的SLE患者的眼表情况,并且TNF-α可作为一个有效血清学指标反映眼表状况。展开更多
We report a compact experimental setup for producing a quantum degenerate mixture of Bose23Na and Fermi40K gases. The atoms are collected in dual dark magneto–optical traps(MOT) with species timesharing loading to re...We report a compact experimental setup for producing a quantum degenerate mixture of Bose23Na and Fermi40K gases. The atoms are collected in dual dark magneto–optical traps(MOT) with species timesharing loading to reduce the light-induced loss, and then further cooled using the gray molasses technique on the D2line for23Na and D1line for40K. The microwave evaporation cooling is used to cool23Na in |F = 2, mF= 2〉 in an optically plugged magnetic trap, meanwhile,40K in |F = 9/2, mF= 9/2〉 is sympathetically cooled. Then the mixture is loaded into a large volume optical dipole trap where23Na atoms are immediately transferred to |1, 1〉 for further effective cooling to avoid the strong three-body loss between23Na atoms in |2, 2〉 and40K atoms in |9/2, 9/2〉. At the end of the evaporation in optical trap, a degenerate Fermi gas of40K with 1.9 × 10^(5) atoms at T/TF= 0.5 in the |9/2, 9/2〉 hyperfine state coexists with a Bose–Einstein condensate(BEC) of23Na with 8 × 10^(4) atoms in the |1, 1〉 hyperfine state at 300 n K. We also can produce the two species mixture with the tunable population imbalance by adjusting the 23Na magneto–optical trap loading time.展开更多
文摘目的探索可能影响不伴有继发性干燥综合征(sSS)的系统性红斑狼疮(SLE)患者发生干眼的细胞因子,并分析有关细胞因子的浓度与临床干眼指标之间的相关性。方法 54例诊断为SLE且符合纳入标准的患者被作为研究对象,根据患者的临床干眼指标分为干眼组( n =11)、干眼倾向组( n =25)、对照组( n =18)。用Western blot法检测各组患者血清中的基质金属蛋白酶2(MMP-2)及激肽释放酶13(Klk13)的含量,通过 ELISA法测量血清中的白介素1(IL-1)、 IL-6、肿瘤坏死因子α(TNF-α)的浓度。结果 MMP-2的蛋白相对表达量在干眼组与对照组之间的差异有统计学意义( P <0.05),IL-1的浓度在干眼倾向组明显高于对照组,差异有统计学意义( P <0.01),TNF-α的蛋白水平在干眼组与对照组之间的差异有统计学意义( P <0.05)。Klk13、IL-6的蛋白表达量在3组之间的差异无统计学意义( P >0.05)。结论 MMP-2、IL-1和TNF-α影响不伴有sSS的SLE患者的眼表情况,并且TNF-α可作为一个有效血清学指标反映眼表状况。
基金supported by the Innovation Program for Quantum Science and Technology (Grant No. 2021ZD0302003)the National Key Research and Development Program of China (Grant Nos. 2022YFA1404101, 2018YFA0307601,and 2021YFA1401700)+1 种基金the National Natural Science Foundation of China (Grant Nos. 12034011, 92065108, 11974224, 12022406, and 12004229)the Fund for Shanxi 1331 Project Key Subjects Construction。
文摘We report a compact experimental setup for producing a quantum degenerate mixture of Bose23Na and Fermi40K gases. The atoms are collected in dual dark magneto–optical traps(MOT) with species timesharing loading to reduce the light-induced loss, and then further cooled using the gray molasses technique on the D2line for23Na and D1line for40K. The microwave evaporation cooling is used to cool23Na in |F = 2, mF= 2〉 in an optically plugged magnetic trap, meanwhile,40K in |F = 9/2, mF= 9/2〉 is sympathetically cooled. Then the mixture is loaded into a large volume optical dipole trap where23Na atoms are immediately transferred to |1, 1〉 for further effective cooling to avoid the strong three-body loss between23Na atoms in |2, 2〉 and40K atoms in |9/2, 9/2〉. At the end of the evaporation in optical trap, a degenerate Fermi gas of40K with 1.9 × 10^(5) atoms at T/TF= 0.5 in the |9/2, 9/2〉 hyperfine state coexists with a Bose–Einstein condensate(BEC) of23Na with 8 × 10^(4) atoms in the |1, 1〉 hyperfine state at 300 n K. We also can produce the two species mixture with the tunable population imbalance by adjusting the 23Na magneto–optical trap loading time.
