Proliferating cell nuclear antigen (PCNA) is a cell-cycle-related nuclear protein, which is essential for DNAsynthesis. It could reflect cell proliferating activity. Andthere're reports that it has got relationshi...Proliferating cell nuclear antigen (PCNA) is a cell-cycle-related nuclear protein, which is essential for DNAsynthesis. It could reflect cell proliferating activity. Andthere're reports that it has got relationship withprognosis of many tumors. Immunohistochemistry wasused to detect the expression of PCNA in medullo-blastoma and to study its relationship with prognosis,differentiation, histological classification, size and mitoticindex. The results showed that the expression of PCNA isrelated significantly only with the proguosis, i.e. the lowerthe expression, the better the prognosis. But norelationship of the expression of PCNA withdifferentiation, histological classification, size and mitoticindex of the tumor could be found.展开更多
文摘Proliferating cell nuclear antigen (PCNA) is a cell-cycle-related nuclear protein, which is essential for DNAsynthesis. It could reflect cell proliferating activity. Andthere're reports that it has got relationship withprognosis of many tumors. Immunohistochemistry wasused to detect the expression of PCNA in medullo-blastoma and to study its relationship with prognosis,differentiation, histological classification, size and mitoticindex. The results showed that the expression of PCNA isrelated significantly only with the proguosis, i.e. the lowerthe expression, the better the prognosis. But norelationship of the expression of PCNA withdifferentiation, histological classification, size and mitoticindex of the tumor could be found.
