Objective To evaluate the relationship between plasma apoA Ⅳ levels and coronary atherosclerosis and to explore its relation to other risk factors Methods Using ELISA techniques, plasma apoA Ⅳ levels were quant...Objective To evaluate the relationship between plasma apoA Ⅳ levels and coronary atherosclerosis and to explore its relation to other risk factors Methods Using ELISA techniques, plasma apoA Ⅳ levels were quantified in 181 patients who underwent coronary angiography (CAG) Patients were divided according to their coronary status into a coronary heart disease (CHD) group (stenotic lesion on CAG, n=118) and a control group (normal CAG, n=63) The severity of atherosclerosis was assessed by stenosis scoring of the different lesions Other parameters, including apoA Ⅰ, apoB, Lp(a), HDL C, LDL C, TG, and TC, were measured as well Univariate, logistic regression analyses were used to define the relationship between coronary atherosclerosis and plasma apoA Ⅳ levels Results When compared with the control group, plasma apoA Ⅳ levels were found to be lower in the CHD group There was a weak negative correlation between plasma apoA Ⅳ levels and the severity of coronary atherosclerosis ApoA Ⅳ was found to be a relatively independent risk factor for CHD We also found a positive correlation between apoA Ⅳ and triglyceride levels Conclusions ApoA Ⅳ may be important in the prediction of CHD and coronary atherosclerosis severity It may also play an important role in the metabolism of triglycerides展开更多
文摘Objective To evaluate the relationship between plasma apoA Ⅳ levels and coronary atherosclerosis and to explore its relation to other risk factors Methods Using ELISA techniques, plasma apoA Ⅳ levels were quantified in 181 patients who underwent coronary angiography (CAG) Patients were divided according to their coronary status into a coronary heart disease (CHD) group (stenotic lesion on CAG, n=118) and a control group (normal CAG, n=63) The severity of atherosclerosis was assessed by stenosis scoring of the different lesions Other parameters, including apoA Ⅰ, apoB, Lp(a), HDL C, LDL C, TG, and TC, were measured as well Univariate, logistic regression analyses were used to define the relationship between coronary atherosclerosis and plasma apoA Ⅳ levels Results When compared with the control group, plasma apoA Ⅳ levels were found to be lower in the CHD group There was a weak negative correlation between plasma apoA Ⅳ levels and the severity of coronary atherosclerosis ApoA Ⅳ was found to be a relatively independent risk factor for CHD We also found a positive correlation between apoA Ⅳ and triglyceride levels Conclusions ApoA Ⅳ may be important in the prediction of CHD and coronary atherosclerosis severity It may also play an important role in the metabolism of triglycerides
