This article provides a review of complications and prevetion of interventional therapy of gynecologic tumors With the development of interventional radiology, interventional therapy plays an important role in the tre...This article provides a review of complications and prevetion of interventional therapy of gynecologic tumors With the development of interventional radiology, interventional therapy plays an important role in the treatment of gynecologic tumors, and complications are hardly to be avoided The complications are as following:(1)complications caused by puncture and incubation: such as local haematoma in the site of puncture, thrombus in the lower limb and thrombosis, infection, injury of tunica intima, perforating the artery and catheter knot, etc All of those can be prevented by careful operation; (2)complications caused by contrast medium, it can cause allergy, hypersensitive dermal reaction, mild and severe systemic reaction All need to treat prudently and need corresponding management (3)complications associated with thrombus, such as fever, shedding of embolic agent and reflux, pain in buttocks nd paralysis of lower limbs, etc Patients should be carefully observed, and when those complications occurred it also needs corresponding management; Some patients with liver metastasis may undergo hepatic artery embolism therapy It can cause liver dysfunction, ascites, blood coagulation dysfunction, etc In patients with lung metastasis, it may be also necessary to undergo selective lung artary embolism Patients may occured cough,expectoration and coughing up blood When intercostal arteries are embolized, it will cause injury of spinal cord, but it is rare, numbness of the lower limbs, declination of myodynamia and disorders of defecation and miction will occure (4)complications associated with chemotherapeutic agents, all those agents have different degree adverse effect and toxicity to liver, kindey and bone marrow, they cause gastrointestinal tract discomfort and inhibition of bone marrow So blood, ECG, function of liver and kindey should be regularly monitored Additionally, they cause the region where agents perfused disorder of blood supply, dermal pigmentation and dermal necrosis All those complications mentioned above can be successfully managed if it can be prevented by sufficient pre operative prepareration and carefully post operative展开更多
目的在中国汉族人群中研究与2/3级紫杉醇介导的外周感觉神经病变(PSN)相关的单核苷酸基因多态性(SNP)位点及临床特点。方法以2014年5月至2016年12月在北京协和医院接受紫杉醇方案化疗的216例患者为研究对象,提取外周血DNA,选取8个候选SN...目的在中国汉族人群中研究与2/3级紫杉醇介导的外周感觉神经病变(PSN)相关的单核苷酸基因多态性(SNP)位点及临床特点。方法以2014年5月至2016年12月在北京协和医院接受紫杉醇方案化疗的216例患者为研究对象,提取外周血DNA,选取8个候选SNP位点,采用Sequenom Mass ARRARYi PLEX平台测定基因型。依据美国国家癌症研究院-不良反应常见术语评定标准,由受训的临床医生完成患者随访及PSN分级。结果共有209例患者最终纳入分析。在候选SNP位点中,仅rs4141404∶A>C(LIMK2)与2/3级PSN显著相关(OR:4.32,95%CI:2.37~7.89,P<0.0001)。多因素Logistic回归分析结果显示,rs4141404∶A>C(LIMK2)多态性及既往使用铂类制剂(OR:2.70,95%CI:1.32~5.51,P=0.007)与2/3级PSN发生风险相关。结论 rs4141404∶A>C(LIMK2)多态性可能是中国汉族人群发生紫杉醇介导的2/3级PSN的风险因素。展开更多
文摘This article provides a review of complications and prevetion of interventional therapy of gynecologic tumors With the development of interventional radiology, interventional therapy plays an important role in the treatment of gynecologic tumors, and complications are hardly to be avoided The complications are as following:(1)complications caused by puncture and incubation: such as local haematoma in the site of puncture, thrombus in the lower limb and thrombosis, infection, injury of tunica intima, perforating the artery and catheter knot, etc All of those can be prevented by careful operation; (2)complications caused by contrast medium, it can cause allergy, hypersensitive dermal reaction, mild and severe systemic reaction All need to treat prudently and need corresponding management (3)complications associated with thrombus, such as fever, shedding of embolic agent and reflux, pain in buttocks nd paralysis of lower limbs, etc Patients should be carefully observed, and when those complications occurred it also needs corresponding management; Some patients with liver metastasis may undergo hepatic artery embolism therapy It can cause liver dysfunction, ascites, blood coagulation dysfunction, etc In patients with lung metastasis, it may be also necessary to undergo selective lung artary embolism Patients may occured cough,expectoration and coughing up blood When intercostal arteries are embolized, it will cause injury of spinal cord, but it is rare, numbness of the lower limbs, declination of myodynamia and disorders of defecation and miction will occure (4)complications associated with chemotherapeutic agents, all those agents have different degree adverse effect and toxicity to liver, kindey and bone marrow, they cause gastrointestinal tract discomfort and inhibition of bone marrow So blood, ECG, function of liver and kindey should be regularly monitored Additionally, they cause the region where agents perfused disorder of blood supply, dermal pigmentation and dermal necrosis All those complications mentioned above can be successfully managed if it can be prevented by sufficient pre operative prepareration and carefully post operative
文摘目的在中国汉族人群中研究与2/3级紫杉醇介导的外周感觉神经病变(PSN)相关的单核苷酸基因多态性(SNP)位点及临床特点。方法以2014年5月至2016年12月在北京协和医院接受紫杉醇方案化疗的216例患者为研究对象,提取外周血DNA,选取8个候选SNP位点,采用Sequenom Mass ARRARYi PLEX平台测定基因型。依据美国国家癌症研究院-不良反应常见术语评定标准,由受训的临床医生完成患者随访及PSN分级。结果共有209例患者最终纳入分析。在候选SNP位点中,仅rs4141404∶A>C(LIMK2)与2/3级PSN显著相关(OR:4.32,95%CI:2.37~7.89,P<0.0001)。多因素Logistic回归分析结果显示,rs4141404∶A>C(LIMK2)多态性及既往使用铂类制剂(OR:2.70,95%CI:1.32~5.51,P=0.007)与2/3级PSN发生风险相关。结论 rs4141404∶A>C(LIMK2)多态性可能是中国汉族人群发生紫杉醇介导的2/3级PSN的风险因素。
