From 1959 through to May, 1993, 363 patients with adenocarcinoma of uterine cervix were initially treated which accounted for 2.5% of all initially treated cases with cervical carcinoma. Paticnts’mean age was 50.5yea...From 1959 through to May, 1993, 363 patients with adenocarcinoma of uterine cervix were initially treated which accounted for 2.5% of all initially treated cases with cervical carcinoma. Paticnts’mean age was 50.5years. 46% of the cases were post-menopausal. The main symptom was irregular vaginal bleeding and/or discharge.Over 88% of the cases were in stage Ⅱ and Ⅲ of the discase, thcy were treated with radiotherapy alone. The ovcrall 5-years survival rate was 51.8%. The recurrence rate was 17.4% with a mean time to recurrence of 33.3months Thirteen patients recurred beyond 5 years.Recurrence was accompanied with lung metastasis in 17patients and supraclavicular lymph node metastasis in 11.Among Patients whose tumor recurred the 1- and 2- year survival rate were 35.2% and 19.2% respectively. The most significant Prognostic factors were the stage of disease, the size of the tumor and the histologic subtyes.展开更多
目的：探讨原发性卵巢小细胞癌（Small Cell Carcinoma of the Ovary，SCCO）临床病理特点、诊断、治疗及预后。方法：对中国医学科学院肿瘤医院2005年1月至2012年12月收治的4例SCCO病例资料进行回顾性分析。结果：4例SCCO患者平均发病...目的：探讨原发性卵巢小细胞癌（Small Cell Carcinoma of the Ovary，SCCO）临床病理特点、诊断、治疗及预后。方法：对中国医学科学院肿瘤医院2005年1月至2012年12月收治的4例SCCO病例资料进行回顾性分析。结果：4例SCCO患者平均发病年龄43.75（17～57）岁；绝经后2例，〈30岁l例。Ⅰ期1例，Ⅲ～Ⅳ期3例。除1例无法分型外，余3例均为肺型。4例患者中1例行保留生育功能手术，3例行减瘤术；4例患者术后均给予铂类为基础的多药联合化疗，3例行TC方案化疗，无术后放疗者。本组治疗后随诊7～30个月，2例于初次诊断后的9、12个月死于本病，2例治疗后分别生存7、30个月，无复发迹象。结论：SCCO较罕见，预后差，免疫组织化学检测可用于鉴别诊断。治疗上以减瘤术及术后铂类为基础化疗为主要手段，最优化疗方案仍需进一步研究。展开更多
文摘From 1959 through to May, 1993, 363 patients with adenocarcinoma of uterine cervix were initially treated which accounted for 2.5% of all initially treated cases with cervical carcinoma. Paticnts’mean age was 50.5years. 46% of the cases were post-menopausal. The main symptom was irregular vaginal bleeding and/or discharge.Over 88% of the cases were in stage Ⅱ and Ⅲ of the discase, thcy were treated with radiotherapy alone. The ovcrall 5-years survival rate was 51.8%. The recurrence rate was 17.4% with a mean time to recurrence of 33.3months Thirteen patients recurred beyond 5 years.Recurrence was accompanied with lung metastasis in 17patients and supraclavicular lymph node metastasis in 11.Among Patients whose tumor recurred the 1- and 2- year survival rate were 35.2% and 19.2% respectively. The most significant Prognostic factors were the stage of disease, the size of the tumor and the histologic subtyes.
文摘目的：探讨原发性卵巢小细胞癌（Small Cell Carcinoma of the Ovary，SCCO）临床病理特点、诊断、治疗及预后。方法：对中国医学科学院肿瘤医院2005年1月至2012年12月收治的4例SCCO病例资料进行回顾性分析。结果：4例SCCO患者平均发病年龄43.75（17～57）岁；绝经后2例，〈30岁l例。Ⅰ期1例，Ⅲ～Ⅳ期3例。除1例无法分型外，余3例均为肺型。4例患者中1例行保留生育功能手术，3例行减瘤术；4例患者术后均给予铂类为基础的多药联合化疗，3例行TC方案化疗，无术后放疗者。本组治疗后随诊7～30个月，2例于初次诊断后的9、12个月死于本病，2例治疗后分别生存7、30个月，无复发迹象。结论：SCCO较罕见，预后差，免疫组织化学检测可用于鉴别诊断。治疗上以减瘤术及术后铂类为基础化疗为主要手段，最优化疗方案仍需进一步研究。
