Antimicrobial resistance(AMR)is unquestionably-one of the most severe,international public health crises that mankind faces now and in the next decades,with the latest data indicating global deaths quintuple over the ...Antimicrobial resistance(AMR)is unquestionably-one of the most severe,international public health crises that mankind faces now and in the next decades,with the latest data indicating global deaths quintuple over the past five years to claim nearly 5 million lives[1],which seems substantially underestimated the projected health impact(10 million deaths)and economic burden(US$100 trillion)of AMR by 2050[2].To counteract the burgeoning AMR crisis,the One Health initiative has called for international collective effort in improving human,animal and environmental health through integrated management of this interfacial triad.Among which,the environmental dimension is often underrepresented,especially soil compartment as the origin,reservoir and transmission route for propagating antibiotic resistance genes(ARGs)in microbiota that exacerbate AMR[3].展开更多
基金supported by the National Key Research and Development Program of China(2020YFC1806903)the National Natural Science Foundation of China(22193061,22222607,and 42150410392).
文摘Antimicrobial resistance(AMR)is unquestionably-one of the most severe,international public health crises that mankind faces now and in the next decades,with the latest data indicating global deaths quintuple over the past five years to claim nearly 5 million lives[1],which seems substantially underestimated the projected health impact(10 million deaths)and economic burden(US$100 trillion)of AMR by 2050[2].To counteract the burgeoning AMR crisis,the One Health initiative has called for international collective effort in improving human,animal and environmental health through integrated management of this interfacial triad.Among which,the environmental dimension is often underrepresented,especially soil compartment as the origin,reservoir and transmission route for propagating antibiotic resistance genes(ARGs)in microbiota that exacerbate AMR[3].
