基金supported by the National Key R&D Program of China(2021YFC2701101)the National Natural Science Foundation of China(82150008,81930036,and 81970572)+1 种基金the Commission for Science and Technology of Shanghai Municipality(20JC1418500 and 20ZR1404800)the Open Fund Project of Guangdong Academy of Medical Sciences(YKY-KF202202)。