Studies on the mechanism of the reactions involving coenzyme NAD(P)H and its model compounds are of considerable significance for understanding the role and the mechanism of this coenzyme in living cells. Although the...Studies on the mechanism of the reactions involving coenzyme NAD(P)H and its model compounds are of considerable significance for understanding the role and the mechanism of this coenzyme in living cells. Although there have been extensive studies on the mechanism of hydride transfer for NADH and its models, a展开更多
Recently, it was found in this laboratory that nitroxide is an oxidant for some biologically active substances, e. g., ascorbic acid and cysteine, and some mechanistic studies involving electron transfer have been rep...Recently, it was found in this laboratory that nitroxide is an oxidant for some biologically active substances, e. g., ascorbic acid and cysteine, and some mechanistic studies involving electron transfer have been reported. In this letter we wish to report a detailed study on the redox reaction between 2,2,6, 6-tetramethyl-4-hydroxypiperidine nitroxide (Ⅰ)展开更多
Studies on the protective action of glutathione (1) via the destruction of free radicals in biological system are of great significance. The authors have previously reported the reaction of glutathione with 2,2, 6,6-t...Studies on the protective action of glutathione (1) via the destruction of free radicals in biological system are of great significance. The authors have previously reported the reaction of glutathione with 2,2, 6,6-tetramethyl-4-hydroxypiperidine-1-展开更多
文摘Studies on the mechanism of the reactions involving coenzyme NAD(P)H and its model compounds are of considerable significance for understanding the role and the mechanism of this coenzyme in living cells. Although there have been extensive studies on the mechanism of hydride transfer for NADH and its models, a
文摘Recently, it was found in this laboratory that nitroxide is an oxidant for some biologically active substances, e. g., ascorbic acid and cysteine, and some mechanistic studies involving electron transfer have been reported. In this letter we wish to report a detailed study on the redox reaction between 2,2,6, 6-tetramethyl-4-hydroxypiperidine nitroxide (Ⅰ)
文摘Studies on the protective action of glutathione (1) via the destruction of free radicals in biological system are of great significance. The authors have previously reported the reaction of glutathione with 2,2, 6,6-tetramethyl-4-hydroxypiperidine-1-