Recently, much attention has been focussed on the isolation and the functional roles of mammalian atrial peptides which have been known to exert profound natriuretic and diuretic activities, implying their possible ro...Recently, much attention has been focussed on the isolation and the functional roles of mammalian atrial peptides which have been known to exert profound natriuretic and diuretic activities, implying their possible role in the control of extracellular fluid volume and electrolytes homestasis. Moreover, one of the bovine atrial peptide, AAP, has been proved to exhibit significant antiarrhythmic activity on the cultured myocar-展开更多
Maytansinol (1) is the common precursor of maytansinoids (2), which are the 3-0-acyl derivatives of 1 and generally show antitumor activities in animal trials.Maytansinol 1 has been obtained in quantity by means of fe...Maytansinol (1) is the common precursor of maytansinoids (2), which are the 3-0-acyl derivatives of 1 and generally show antitumor activities in animal trials.Maytansinol 1 has been obtained in quantity by means of fermentation and converted synthetically into maytansinoids by Japanese investigators. The novel and complicated structure of 1 was looked upon as a challenge to synthetic chemists.展开更多
文摘Recently, much attention has been focussed on the isolation and the functional roles of mammalian atrial peptides which have been known to exert profound natriuretic and diuretic activities, implying their possible role in the control of extracellular fluid volume and electrolytes homestasis. Moreover, one of the bovine atrial peptide, AAP, has been proved to exhibit significant antiarrhythmic activity on the cultured myocar-
文摘Maytansinol (1) is the common precursor of maytansinoids (2), which are the 3-0-acyl derivatives of 1 and generally show antitumor activities in animal trials.Maytansinol 1 has been obtained in quantity by means of fermentation and converted synthetically into maytansinoids by Japanese investigators. The novel and complicated structure of 1 was looked upon as a challenge to synthetic chemists.
