电针干预周围神经损伤效应及机制的研究

周围神经损伤(PNI)是临床常见病,属于中医“痹证”“痿证”范畴。本着“评价疗效、探寻规律、阐明机制、指导临床”为研究总体思路,天津中医药大学实验针灸学研究中心郭义教授团队与日本铃鹿医疗科学大学石田寅夫教授团队合作,围绕电针治疗周围神经损伤开展了系列研究。明确了电针刺激可促进外周神经再生,早期干预效果更佳,低频电针效果更佳,且对失神经支配所造成的肌肉萎缩也有一定的疗效,肯定了经皮穴位电刺激治疗可显著改善糖尿病患者的临床症状,提高生命质量,可改善病变神经的运动和感觉功能。并从形态学、分子生物学角度明确了其干预机制。研究为临床更好使用电针治疗周围神经损伤提供了科学依据,推动了电针治疗神经损伤的临床应用。

一氧化氮参与内毒素引起大鼠肝药酶活性下降的实验研究

已有的研究表明,肺炎杆菌内毒素降低肝药酶活性与内毒素的剂量具有相关性,为了阐明革兰氏阴性细菌感染时,一氧化氮(NO)在降低肝药物代谢酶活性中的作用,本研究以安替吡林为模型药物,研究其在经内毒素处理和/或诱导型NO合成酶(iNOS)的选择性抑制剂SMT处理的大鼠中体内药代动力学特点。腹腔注射1mg/kg内毒素可以显著降低安替吡林的系统清除率,这表明内毒素引起肝药物代谢酶活性的降低;

日本刺络疗法浅探

追溯日本刺络疗法的历史,介绍日本刺络疗法的现状与特色。日本的刺络疗法起源于中国,结合其对于刺络疗法的认识,并吸收葡萄牙医学和荷兰医学中有关刺血、泻血的理论与实践的精华。近代工藤训正对刺络理论和技术方面的论述成为现在日本刺络疗法的标准,在此基础上浅见铁男等又提出了新的刺络疗法理论,使日本的刺络疗法日臻完善。现在刺络疗法作为日本医疗体系的一部分,正在逐渐得到日本医疗界的重视,并形成了具有日本特色的刺络疗法。

针灸治疗抑郁症患者随机对照试验研究报告质量

目的通过分析和评价针灸治疗抑郁症随机对照试验的报告质量，了解现阶段针灸治疗抑郁症随机对照试验的研究现状。方法检索的中文数据库包括中国期刊全文数据库（CNKI，2005至2010年），维普信息资源系统（wEIPu，2005至2010年），医中志（日本）的国内外有关针灸治疗抑郁症的临床研究文献。中文检索关键词为抑郁、郁证、针、针灸、针剌、电针、拔罐、埋线、注射、穴位、经络、耳针等。日本检索关键词为 、ぅっ、针灸、缄灸等。采用针灸随机对照试验报告标准（STRICTA）和随机对照试验报告统一标准（CONSORT）评价针灸治疗抑郁症随机对照试验报告质量。结果按照CONSORT和STRICTA报告规范标准，现阶段针灸治疗抑郁症随机对照试验的报告不够规范。结论建议采用国际通用的CONSORT和STRICTA报告规范标准，提高研究的报告质量。加强研究设计、提高研究质量、保证证据一致性和直接性，探索符合中医特色的研究方法，提高证据水平，进而提高推荐强度。

日本针灸标准研制现状及其对一些问题的思考

从国家标准、行业标准及企业标准3方面介绍日本针灸标准的研制现状。日本现有一项国家标准,即一次性毫针标准,有9项行业标准和若干企业标准。日本针灸标准化的一些问题是数量偏少,在一些重要领域没有相应的标准,同时由于日本政府的重视度尚不够,来自国家的支持也少,日本针灸标准化刚刚起步,还需要进一步的发展。

Observation on the effect of acupoint stimulation on regional cerebral blood flow using near-infrared spectroscopy technology

Objective To observe the effect of acupuncture at Kongzui（孔最LU 6）,Sanyinjiao（三阴交 SP 6） and Zusanli（足三里 ST 36） on cerebral blood oxygenation level and explore the relevance between acupuncture and cerebral blood oxygenation level using near-infrared spectroscopy（NIRS）.Methods Quasi-randomized design（random test sequence） was used.In clinical trial ①,placebo acupuncture was applied at Baihui（百会GV 20） of18 adults.In clinical trial ②,54 adults were divided into three groups with 18 each in which acupuncture was applied at LU 6,SP 6 and ST 36 respectively.Before and after acupuncture,verbal fluency test（VFT） was performed and the blood oxygenation level of cerebral cortex was measured using NIRS.Quantized data was processed with JMP10.0.2 software and SPSS software.Results In clinical trial ①,the mean integral values of cerebral blood oxygenation level were 10.8 mMcm·s and 9.2 mMcm·s respectively before and after acupuncture at GV 20 in placebo acupuncture group.There was no significant difference in the cerebral blood oxygenation level after acupuncture.In clinical trial ②,the mean integral values of cerebral blood oxygen level were18.1 mMcm·s and 8.6 mMcm·s respectively before and after acupuncture at LU 6 in[LU 6]acupuncture group,the cerebral blood oxygenation level was significantly decreased after acupuncture（P = 0.001）.The mean integral values of cerebral blood oxygenation level were 16.1 mMcm·s and 17.4 mMcm·s respectively before and after acupuncture at SP 6 in[SP 6]acupuncture group,the cerebral blood oxygenation level was slightly increased after acupuncture,but the increase was not statistically significant.The mean integral values of cerebral blood oxygenation level were 13.8 mMcnvs and 10.1 mMcnvs respectively before and after acupuncture at ST 36 in[ST 36]acupuncture group,the cerebral blood oxygenation level was slightly deceased after acupuncture,but the increase was not statistically significant.Conclusion The cerebral blood oxygenation level of frontal head was decreased by acupuncture at LU 6,the cerebral blood oxygenation level of frontal head was intended to decrease by acupuncture at ST 36.The cerebral blood oxygenation level of frontal head is intended to increase by acupuncture at SP 6.

Point selection characteristics and rules of acupuncture in treatment of depression based on data mining

Objective To discuss the point selection characteristics and rules of prescription for acupuncture in treatment of depression. Method Clinical literature on acupuncture in treatment of depression in recent five years were retrieved by retrospective document research; the number of point and use frequency were calculated, and their characteristics and rules were analyzed by means of bibliometrics. Result One hundred and seventy-seven papers about acupuncture in treatment of depression were retrieved with 158 acupoints used for 1 630 times in total, including B ihuì（百会 GV 20）, Tàichōng（太冲 LR 3）, Sānyīnjiāo（三阴交 SP 6）, and Shénmén（神门 HT 7）, which were used most frequently. In view of meridians, governor vessel, the foot-taiyang bladder meridian and the foot-jueyin liver meridian were used most frequently, fiveshu points were used frequently in specific points, and the most frequently used point combination was distal and local point combination. Conclusion The primary prescription for acupuncture in treatment of depression is GV 20 in combination with distal LR 3, SP 6, HT 7, and other points.