目的探讨胸膜孤立性纤维瘤(solitary fibrous tumor of the pleura,SFTP)的诊断和外科治疗。方法回顾分析本院胸外科1997年4月至2007年4月间收治的16例胸膜孤立性纤维瘤的临床资料。结果气短(62.5%)、胸痛(43.8%)、咳嗽(31.2%)、咳痰(25...目的探讨胸膜孤立性纤维瘤(solitary fibrous tumor of the pleura,SFTP)的诊断和外科治疗。方法回顾分析本院胸外科1997年4月至2007年4月间收治的16例胸膜孤立性纤维瘤的临床资料。结果气短(62.5%)、胸痛(43.8%)、咳嗽(31.2%)、咳痰(25.0%)是SFTP的主要症状。病变位于左侧胸腔者9例(56.2%),右侧胸腔7例(43.8%)。肿瘤来源于脏层胸膜2例(12.5%),均有蒂;来源于壁层胸膜14例(87.5%),均无蒂,宽基底。均无石棉接触史。术前诊断正确率为18.8%,误诊率为81.2%。本组诊断主要依据免疫组化分析,所有患者的CD34和vimentin均阳性表达,而cytokeratin,desmin,S-100,Ki-67均阴性表达。本组均行根治性切除,手术切除率为100%,无围手术期死亡。术后发生并发症2例,并发症发生率为12.5%。随访6个月至10年,平均随访57个月,中位随访期49个月,有1例复发,均存活,无转移。结论胸膜孤立性纤维瘤的诊断主要依靠免疫组化分析,根治性切除是主要治疗手段。展开更多
背景与目的肺癌是世界范围内发病率和死亡率最高的恶性肿瘤之一,手术仍然是早期非小细胞肺癌的首选治疗方法。本研究的目的是探讨术后极早期肺功能的恢复情况,并比较肺癌胸腔镜肺叶切除、胸腔镜肺段切除与开胸肺叶切除术后对肺功能影响...背景与目的肺癌是世界范围内发病率和死亡率最高的恶性肿瘤之一,手术仍然是早期非小细胞肺癌的首选治疗方法。本研究的目的是探讨术后极早期肺功能的恢复情况,并比较肺癌胸腔镜肺叶切除、胸腔镜肺段切除与开胸肺叶切除术后对肺功能影响。方法选取中国医学科学院肿瘤医院胸外科2015年9月-2016年2月间手术的肺癌患者,按术式不同分为胸腔镜肺段切除术组、胸腔镜肺叶切除术组、开胸肺叶切除术组,分别于术前、术后第3天和术后3个月检查测试肺功能。统计分析采用SPSS 20.0版本,应用单因素方差分析,比较组间差异。结果 1在术后第3天,对比胸腔镜肺叶切除术、胸腔镜肺段切除术、开胸肺叶切除术,三组患者的肺功能,用力肺活量(forced vital capacity,FVC)、FVC占预计值的百分比(FVC%)、一秒用力呼气容积(forced expiratory volume in one second,FEV1)、FEV1占预计值的百分比(FEV1%)、最大呼气流速峰值(peak expiratory flow,PEF)、每分钟最大通气量(maximal voluntary ventilation,MVV)、肺一氧化碳弥散因子(transfer factor for carbon monoxide of lung,TLCO)、TLCO占预计值的百分比(TLCO%),组间差异具有统计学意义(P值分别为0.033、0.042、0.029、0.045、0.039、0.021、0.018、0.024)。2在术后3个月,对比胸腔镜肺叶切除术、胸腔镜肺段切除术、开胸肺叶切除术,三组患者的肺功能,组间比较发现FVC、FVC%、FEV1、FEV1%、PEF、MVV、TLCO、TLCO%差异显著(P值分别为0.019、0.024、0.044、0.021、0.037、0.029、0.045、0.017)。结论肺癌胸腔镜肺叶切除、胸腔镜肺段切除与开胸肺叶切除术后在术后极早期(术后第3天)与术后3个月,肺功能的恢复情况均为胸腔镜肺段切除优于胸腔镜肺叶切除,胸腔镜肺叶切除优于开胸肺叶切除。展开更多
Objective： A retrospective study was performed to analyze the impact of vascular invasion on prognosis in a series of radically resected non-small cell lung cancer （NSCLC） and the subgroup of T1-4 nodal negative NS...Objective： A retrospective study was performed to analyze the impact of vascular invasion on prognosis in a series of radically resected non-small cell lung cancer （NSCLC） and the subgroup of T1-4 nodal negative NSCLC patients. Methods： A total of 259 NSCLC patients who had undergone radical resection were entered into this study. Detailed clinical data including five-year survival were obtained for all the patients. The tumors were reviewed for the presence or absence of vascular invasion. Fisher＇s exact tests were used to assess the relationship between vascular invasion and other clinicopathological variables. Survival time was defined as the interval from the date of operation to either death from lung cancer or the last follow-up. Univariate analysis of survival curve was performed by the Kaplan-Meier method using the Log rank test. Multivariate survival analysis was carried out by Cox regression. P〈0.05 was considered statistically significant. Results： In 259 patients, 33 cases were diagnosed as having vascular invasion. The overall 5-year survival was 37.5%. Patients with vascular invasion had a median survival of 20 months compared with 43 months for those without vascular invasion （P〈0.01）. Multivariate analysis indicated that vascular invasion was a significant independent prognostic predictor for shortened cancer-related survival in the patients. The relative risk for cancer-related survival was 2.2-fold greater in patients with vascular invasion （95% CI： 1.45-3.32）. Subgroup analysis revealed that patients with vascular invasion had a 5-year survival of 11.1% compared with 57.1% for those without vascular invasion in the resected lung cancer patients at T1-4N0M0 （P=0.002）. Conclusion： Vascular invasion can serve as an independent prognostic factor in radically resected NSCLC.展开更多
目的:通过整合肺腺癌(lung adenocarcinoma,LUAD)临床信息组、基因组和转录组的多组学信息,构建预后相关风险预测模型,为肺腺癌患者的预后风险预测提供依据。方法:通过肿瘤基因图谱(the cancer genome atlas,TCGA)网站下载522例肺腺癌...目的:通过整合肺腺癌(lung adenocarcinoma,LUAD)临床信息组、基因组和转录组的多组学信息,构建预后相关风险预测模型,为肺腺癌患者的预后风险预测提供依据。方法:通过肿瘤基因图谱(the cancer genome atlas,TCGA)网站下载522例肺腺癌患者数据,完成肺腺癌患者多组学数据库构建。对经过质量控制的数据库,采用Cox比例风险模型评价多组学数据对LUAD预后的影响,构建基于临床信息、基因分型和基因表达多组学信息的预后风险预测模型,并使用受试者工作特征(receiver operating characteristic,ROC)曲线和曲线下面积(area under curve,AUC)评估预后模型风险识别的能力。结果:共386例肺腺癌患者纳入多组学数据库,分别筛选出1个临床信息组、5个基因组单核苷酸多态性(single nucleotide polymorphisms,SNP)和4个转录组mRNA预后相关特征因素与肺腺癌的预后相关。与肺腺癌低风险组相比,高风险组患者较低风险组的预后更差(HR=3.67,95%CI=2.46～5.49,P=1.96×10-10),联合基因组、转录组与临床信息构建多组学预后指数后,其ROC曲线下面积为0.694(95%CI=0.633～0.754)。结论:采用联合临床信息组、基因组和转录组特征的多组学信息构建的预后风险预测指数可有效区分肺腺癌患者预后好坏,其研究结果将为肺腺癌患者的精准治疗提供有效支撑。展开更多
文摘目的探讨胸膜孤立性纤维瘤(solitary fibrous tumor of the pleura,SFTP)的诊断和外科治疗。方法回顾分析本院胸外科1997年4月至2007年4月间收治的16例胸膜孤立性纤维瘤的临床资料。结果气短(62.5%)、胸痛(43.8%)、咳嗽(31.2%)、咳痰(25.0%)是SFTP的主要症状。病变位于左侧胸腔者9例(56.2%),右侧胸腔7例(43.8%)。肿瘤来源于脏层胸膜2例(12.5%),均有蒂;来源于壁层胸膜14例(87.5%),均无蒂,宽基底。均无石棉接触史。术前诊断正确率为18.8%,误诊率为81.2%。本组诊断主要依据免疫组化分析,所有患者的CD34和vimentin均阳性表达,而cytokeratin,desmin,S-100,Ki-67均阴性表达。本组均行根治性切除,手术切除率为100%,无围手术期死亡。术后发生并发症2例,并发症发生率为12.5%。随访6个月至10年,平均随访57个月,中位随访期49个月,有1例复发,均存活,无转移。结论胸膜孤立性纤维瘤的诊断主要依靠免疫组化分析,根治性切除是主要治疗手段。
文摘背景与目的肺癌是世界范围内发病率和死亡率最高的恶性肿瘤之一,手术仍然是早期非小细胞肺癌的首选治疗方法。本研究的目的是探讨术后极早期肺功能的恢复情况,并比较肺癌胸腔镜肺叶切除、胸腔镜肺段切除与开胸肺叶切除术后对肺功能影响。方法选取中国医学科学院肿瘤医院胸外科2015年9月-2016年2月间手术的肺癌患者,按术式不同分为胸腔镜肺段切除术组、胸腔镜肺叶切除术组、开胸肺叶切除术组,分别于术前、术后第3天和术后3个月检查测试肺功能。统计分析采用SPSS 20.0版本,应用单因素方差分析,比较组间差异。结果 1在术后第3天,对比胸腔镜肺叶切除术、胸腔镜肺段切除术、开胸肺叶切除术,三组患者的肺功能,用力肺活量(forced vital capacity,FVC)、FVC占预计值的百分比(FVC%)、一秒用力呼气容积(forced expiratory volume in one second,FEV1)、FEV1占预计值的百分比(FEV1%)、最大呼气流速峰值(peak expiratory flow,PEF)、每分钟最大通气量(maximal voluntary ventilation,MVV)、肺一氧化碳弥散因子(transfer factor for carbon monoxide of lung,TLCO)、TLCO占预计值的百分比(TLCO%),组间差异具有统计学意义(P值分别为0.033、0.042、0.029、0.045、0.039、0.021、0.018、0.024)。2在术后3个月,对比胸腔镜肺叶切除术、胸腔镜肺段切除术、开胸肺叶切除术,三组患者的肺功能,组间比较发现FVC、FVC%、FEV1、FEV1%、PEF、MVV、TLCO、TLCO%差异显著(P值分别为0.019、0.024、0.044、0.021、0.037、0.029、0.045、0.017)。结论肺癌胸腔镜肺叶切除、胸腔镜肺段切除与开胸肺叶切除术后在术后极早期(术后第3天)与术后3个月,肺功能的恢复情况均为胸腔镜肺段切除优于胸腔镜肺叶切除,胸腔镜肺叶切除优于开胸肺叶切除。
基金a grant from the National High Technology ResearchDevelopment Program of China"863 Project"(No.2002BA711A06)Development Program of China"863 Project"(No.2006AA020707)
文摘Objective： A retrospective study was performed to analyze the impact of vascular invasion on prognosis in a series of radically resected non-small cell lung cancer （NSCLC） and the subgroup of T1-4 nodal negative NSCLC patients. Methods： A total of 259 NSCLC patients who had undergone radical resection were entered into this study. Detailed clinical data including five-year survival were obtained for all the patients. The tumors were reviewed for the presence or absence of vascular invasion. Fisher＇s exact tests were used to assess the relationship between vascular invasion and other clinicopathological variables. Survival time was defined as the interval from the date of operation to either death from lung cancer or the last follow-up. Univariate analysis of survival curve was performed by the Kaplan-Meier method using the Log rank test. Multivariate survival analysis was carried out by Cox regression. P〈0.05 was considered statistically significant. Results： In 259 patients, 33 cases were diagnosed as having vascular invasion. The overall 5-year survival was 37.5%. Patients with vascular invasion had a median survival of 20 months compared with 43 months for those without vascular invasion （P〈0.01）. Multivariate analysis indicated that vascular invasion was a significant independent prognostic predictor for shortened cancer-related survival in the patients. The relative risk for cancer-related survival was 2.2-fold greater in patients with vascular invasion （95% CI： 1.45-3.32）. Subgroup analysis revealed that patients with vascular invasion had a 5-year survival of 11.1% compared with 57.1% for those without vascular invasion in the resected lung cancer patients at T1-4N0M0 （P=0.002）. Conclusion： Vascular invasion can serve as an independent prognostic factor in radically resected NSCLC.
