During eukaryotic transcription,the nascent RNA molecules are processed and packed into RNA-protein particles,termed messenger ribonucleoparticles(mRNPs)[1].Precise mRNP assembly is essential for efficient messenger R...During eukaryotic transcription,the nascent RNA molecules are processed and packed into RNA-protein particles,termed messenger ribonucleoparticles(mRNPs)[1].Precise mRNP assembly is essential for efficient messenger RNA(mRNA)processing and export[2].A conserved protein complex called TREX(transcription export complex)plays an important role in mRNP biogenesis[3-6].展开更多
基金supported by grants from the National Key R&D Program of China (2017YFA0504400 to Hong Cheng and 2019YFA0709400 to Guohui Li)the National Natural Science Foundation of China (31525007 and 31930063 to Ming Lei, 31925008 and 31770880 to Hong Cheng, 32071189 to Jian Wu, and 21625302, 21933010, and 31700647 to Guohui Li)+1 种基金the Strategic Priority Research Program of Chinese Academy of Sciences (XDB19000000 to Hong Cheng)the Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support (20181711 to Jian Wu)。
文摘During eukaryotic transcription,the nascent RNA molecules are processed and packed into RNA-protein particles,termed messenger ribonucleoparticles(mRNPs)[1].Precise mRNP assembly is essential for efficient messenger RNA(mRNA)processing and export[2].A conserved protein complex called TREX(transcription export complex)plays an important role in mRNP biogenesis[3-6].
