鱼腥草合剂对db/db糖尿病小鼠肾损伤的影响

目的:比较鱼腥草合剂醇提液和水提液对db/db小鼠肾脏损伤的作用,并探讨鱼腥草合剂防治2型糖尿病肾病的机制。方法:8周龄的db/m和db/db小鼠分为4组:db/m正常小鼠对照组;db/db糖尿病小鼠对照组;db/db糖尿病小鼠鱼腥草合剂醇提液156 mg.kg-1治疗组;db/db糖尿病小鼠鱼腥草合剂水提液156 mg.kg-1治疗组。经鱼腥草合剂ig治疗4,8周后,观察小鼠体重、24 h尿白蛋白(Alb),血清胰岛素(FINS)、空腹血糖(FPG)、胰岛素敏感指数(IAI)等生化指标的情况。结果:鱼腥草合剂在治疗8周后,血糖、胆固醇、24 h尿白蛋白与对照组相比,均有下降,改善了高脂血症、高血糖症、高胰岛素血症。结论:鱼腥草合剂具有改善糖尿病肾病的作用,其作用机制可能与降低微量尿白蛋白及改善胰岛素抵抗相关。

Effect of houttuynia cordata aetherolea on adiponectin and connective tissue growth factor in a rat model of diabetes mellitus

OBJECTIVE:To determine the effect of Houttuynia cordata Aetherolea on connective tissue growth factor and adiponectin in a rat model of diabetes mellitus(DM).METHODS:DM was induced in rats using streptozotocin(STZ) and high glucose-lipid animal feed.Animals were then treated with Houttuynia cordata Aetherolea for 8 weeks.Changes in connective tissue growth factor and adiponectin levels in rats were observed.RESULTS:Connective tissue growth factor and adiponectin levels in rats with DM improved after Houttuynia cordata Aetherolea treatment.CONCLUSION:Houttuynia cordata Aetherolea had a positive effect on rats with DM by reducing levels of connective tissue growth factor and increasing adiponectin levels.