Objective To evaluate the status,differences and factors influencing quality of life(QoL)in patients with chronic graft-versus-host disease(CVHD).Methods From September 2021 to February 2023,a crosssectional study of ...Objective To evaluate the status,differences and factors influencing quality of life(QoL)in patients with chronic graft-versus-host disease(CVHD).Methods From September 2021 to February 2023,a crosssectional study of 140 patients with chronic GVHD was conducted at our center.Symptom burden was assessed by the Lee Symptomatology Scale(LSS),and QoL was assessed by the Medical Outcome Study 36-Item Short-Form Health Survey(SF-36)(version 1)and five-level EuroQoL five-dimensional questionnaire(EQ-5D-5L).Results Datafrom 140 respondents,including 32(22.9%)with mild chronic GVHD,87(62.1%)with moderate chronic GVHD,and 21(15.0%)with severe chronic GVHD,were analyzed.Of the respondents,61.4%were male,and the median transplantation age was 34(15-68)years.The primary diagnoses were acute myeloid leukemia(50.0%),acute lymphoblastic leukemia(20.0%),and myelodysplastic syndrome(15.0%).The common chronic GVHD-affected organs included the skin in 74 patients(52.9%),the eyes in 57 patients(40.7%),and the liver in 50 patients(35.7%).Among the whole cohort,the eye(20.48±23.75),psychological(16.13±17.00),and oral(13.66±20.55)scores were the highest in the LSS group.展开更多
文摘Objective To evaluate the status,differences and factors influencing quality of life(QoL)in patients with chronic graft-versus-host disease(CVHD).Methods From September 2021 to February 2023,a crosssectional study of 140 patients with chronic GVHD was conducted at our center.Symptom burden was assessed by the Lee Symptomatology Scale(LSS),and QoL was assessed by the Medical Outcome Study 36-Item Short-Form Health Survey(SF-36)(version 1)and five-level EuroQoL five-dimensional questionnaire(EQ-5D-5L).Results Datafrom 140 respondents,including 32(22.9%)with mild chronic GVHD,87(62.1%)with moderate chronic GVHD,and 21(15.0%)with severe chronic GVHD,were analyzed.Of the respondents,61.4%were male,and the median transplantation age was 34(15-68)years.The primary diagnoses were acute myeloid leukemia(50.0%),acute lymphoblastic leukemia(20.0%),and myelodysplastic syndrome(15.0%).The common chronic GVHD-affected organs included the skin in 74 patients(52.9%),the eyes in 57 patients(40.7%),and the liver in 50 patients(35.7%).Among the whole cohort,the eye(20.48±23.75),psychological(16.13±17.00),and oral(13.66±20.55)scores were the highest in the LSS group.
