Organic phosphorescence materials with longlived triplet excitons that can highly generate active singlet oxygen(1O2) through the energy transfer with the molecular oxygen under photoexcitation, serve as highly effici...Organic phosphorescence materials with longlived triplet excitons that can highly generate active singlet oxygen(1O2) through the energy transfer with the molecular oxygen under photoexcitation, serve as highly efficient antibacterial agent. Herein, we report bright red-emissive organic phosphorescent nanoparticles(PNPs) based on a metal-free organic phosphor encapsulated with biocompatible block copolymers. The obtained PNPs with an ultra-small particle size of around 5 nm and a long emission lifetime of up to 167 μs showed effective 1O2 generation ability under visible light(410 nm) excitation in aqueous media, which can efficiently eradicate multi-drug resistant bacteria both in vitro and in vivo. This is the first demonstration of metal-free organic PNPs for photodynamic antimicrobial therapy, expanding the application scope of metal-free organic room temperature phosphorescent materials.展开更多
基金supported by the National Key R&D Program of China (2018YFC1105402 and 2017YFA0207202)the National Natural Science Foundation of China (21975120, 21875104, 51673095 and 21875189)+3 种基金the National Basic Research Program of China (973 Program, 2015CB932200)the Natural Science Fund for Distinguished Young Scholars of Jiangsu Province (BK20180037)the Natural Science Fund for Colleges and Universities of Jiangsu Province (17KJB430020)the Key R&D Program of Jiangsu Province (BE2017740)
文摘Organic phosphorescence materials with longlived triplet excitons that can highly generate active singlet oxygen(1O2) through the energy transfer with the molecular oxygen under photoexcitation, serve as highly efficient antibacterial agent. Herein, we report bright red-emissive organic phosphorescent nanoparticles(PNPs) based on a metal-free organic phosphor encapsulated with biocompatible block copolymers. The obtained PNPs with an ultra-small particle size of around 5 nm and a long emission lifetime of up to 167 μs showed effective 1O2 generation ability under visible light(410 nm) excitation in aqueous media, which can efficiently eradicate multi-drug resistant bacteria both in vitro and in vivo. This is the first demonstration of metal-free organic PNPs for photodynamic antimicrobial therapy, expanding the application scope of metal-free organic room temperature phosphorescent materials.
