The phenomenon in which cells prefer glycolysis to oxidative phosphorylation with increased lactate production is known as the Warburg effect and is found prevalent in cancer cells and pluripotent stem cells [1]. In a...The phenomenon in which cells prefer glycolysis to oxidative phosphorylation with increased lactate production is known as the Warburg effect and is found prevalent in cancer cells and pluripotent stem cells [1]. In addition to being an intermediate metabolite of glycolysis, lactate has been reported as a signal involved in multiple important biological processes, such as innate immunity [2], the cell cycle [3], hippocampal neurogenesis [4].展开更多
基金supported by the National Key Research and Development Program of China (2023YFE0210100, 2022YFE0210100, 2019YFA0904500, 2022YFA1103800)the National Natural Science Foundation of China (32025010, 92157202, 32241002, 92254301, 92357302, 32261160376,31970709, 32070729, 32100619, 32170747, 32322022, 32370782, 32371007, 32300608, 32300620)+7 种基金NSFC/RGC Joint Grant Scheme 2022/2023 (N_CUHK 428/22)the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB0480000)the Key Research Program, CAS (ZDBSZRKJZ-TLC003)International Cooperation Program, CAS (154144KYSB20200006)CAS Project for Young Scientists in Basic Research (YSBR-075)Guangdong Province Science and Technology Program (2023B0303000023, 2023B1111050005, 2023A1515030231, 2022A1515110493, 2023B1212060050, 2021A1515012513, 2021B1515020096, 2022A1515012616, 2022A1515110951, 2023B1212120009)Guangzhou Science and Technology Program (202102021037, 202102020827, 202102080066, 202206060002, 2023A04J0414)Health@Inno HK funding support from the Innovation Technology Commission of the Hong Kong SAR, Basic Research Project of Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences and CAS Youth Innovation Promotion Association。
文摘The phenomenon in which cells prefer glycolysis to oxidative phosphorylation with increased lactate production is known as the Warburg effect and is found prevalent in cancer cells and pluripotent stem cells [1]. In addition to being an intermediate metabolite of glycolysis, lactate has been reported as a signal involved in multiple important biological processes, such as innate immunity [2], the cell cycle [3], hippocampal neurogenesis [4].
