目的:系统全面探讨膏方辅助治疗慢性阻塞性肺疾病(COPD)的临床及其相关Meta分析。方法:检索国内外中英文数据库近五年关于膏方治疗COPD的随机试验(RCT),利用Revman 5.3软件开展偏倚风险评价和Meta分析。结果:共纳入22篇文献、研究对象1...目的:系统全面探讨膏方辅助治疗慢性阻塞性肺疾病(COPD)的临床及其相关Meta分析。方法:检索国内外中英文数据库近五年关于膏方治疗COPD的随机试验(RCT),利用Revman 5.3软件开展偏倚风险评价和Meta分析。结果:共纳入22篇文献、研究对象1745例,包括治疗组876例,对照组869例,Meta分析结果表明:与单一西药疗法比较,膏方增强总有效率(TE) [OR = 3.64, 95% CI (2.36, 5.59), P Objective: To systematically and comprehensively investigate the clinical and related Meta-analyses of the adjuvant treatment of chronic obstructive pulmonary disease (COPD) with plaster formula. Methods: Randomized trials (RCTs) of plaster prescriptions for the treatment of COPD in the past five years were searched in Chinese and English databases at home and abroad, and risk of bias assessment and Meta-analysis were carried out using Revman 5.3 software. Result: A total of 22 articles and 1745 study subjects were included, including 876 cases in the treatment group and 869 cases in the control group, and the results of Meta-analysis showed that compared with a single Western drug therapy, the total effective rate (TE) was enhanced by the plaster formula [OR = 3.64, 95% CI (2.36, 5.59), P < 0.00001], increased the percentage of forced expiratory volume in 1 second to predicted value (FEV1%) [MD = 4.91, 95% CI (3.39, 6.43), P < 0.00001], reduced the number of acute exacerbations [MD = −0.34, 95% CI (−0.39, −0.28), P < 0.00001], and the adverse effects were mild and few. Conclusion: The addition of ointment in the treatment of COPD can significantly improve the overall physiological indexes of patients, including alleviating respiratory symptoms, and enhancing patients’ exercise ability and immunity, and has no obvious side effects, therefore, it is recommended to use ointment as an adjuvant drug for COPD, and ensure the safety and effectiveness of the drug through large-scale, high-precision, and multi-point monitoring experiments.展开更多
目前,恶性肿瘤的发病率不断上升,且不断地年轻化,严重影响着人们的生命健康。化疗作为治疗恶性肿瘤的重要手段,通过化疗可以有效延长患者的生存周期,提高患者的生存质量。而骨髓抑制作为化疗常见的毒性反应之一,可导致化疗延期或中断,...目前,恶性肿瘤的发病率不断上升,且不断地年轻化,严重影响着人们的生命健康。化疗作为治疗恶性肿瘤的重要手段,通过化疗可以有效延长患者的生存周期,提高患者的生存质量。而骨髓抑制作为化疗常见的毒性反应之一,可导致化疗延期或中断,影响化疗的疗效。中医药作为我国传统的疾病治疗手段,有着价廉且有效的特点。本文主要对中医在化疗后骨髓抑制的研究现状作一综述。Currently, the incidence rate of malignant tumors is continuously rising and affecting younger age groups, seriously impacting people’s lives and health. As an important means to treat malignant tumors, chemotherapy can effectively prolong the life cycle of patients and improve the quality of life of patients. As one of the common toxic reactions of chemotherapy, myelosuppression can lead to the delay or interruption of chemotherapy and affect the efficacy of chemotherapy. As a traditional means of disease treatment in China, traditional Chinese medicine has the characteristics of being cheap and effective. This article mainly reviews the research status of myelosuppression after chemotherapy in traditional Chinese medicine.展开更多
目的:利用网络药理学及分子对接探究菊花-夏枯草治疗高血压(hypertension)的作用机制。方法:利用TCMSP检测菊花及夏枯草的活性成分,利用GeneCards、OMIM等数据库获取与高血压病的有关靶点,运用Cytoscape软件建立“药物-活性成分-靶点”...目的:利用网络药理学及分子对接探究菊花-夏枯草治疗高血压(hypertension)的作用机制。方法:利用TCMSP检测菊花及夏枯草的活性成分,利用GeneCards、OMIM等数据库获取与高血压病的有关靶点,运用Cytoscape软件建立“药物-活性成分-靶点”的调控网络,利用DAVID6.8进行GO和KEGG富集分析,最后使用Auto Dock Vna1.1.2软件对活性成分与关键靶点之间的分子对接。结论:共筛选出菊花及夏枯草共24个活性成分,高血压潜在治疗靶点157个,得到IL6、IL1B、AKT1、CASP3、TNF、TP53、EGFR、JUN、MMP9、MYC10个重要作用靶点;GO功能富集分析筛选出372条结果,KEGG通道富集包含肿瘤中的通道、流体切应力和动脉粥样硬化等信息通路。分子对接结果显示,主要活性成分与5个核心靶点(IL6、IL1B、AKT1、TNF、TP53)均有较好的亲和力。结论:菊花-夏枯草药对通过多成分、多靶点、多通道防治高血压,为中西医结合防治高血压提供更多的选择。展开更多
文摘目的:系统全面探讨膏方辅助治疗慢性阻塞性肺疾病(COPD)的临床及其相关Meta分析。方法:检索国内外中英文数据库近五年关于膏方治疗COPD的随机试验(RCT),利用Revman 5.3软件开展偏倚风险评价和Meta分析。结果:共纳入22篇文献、研究对象1745例,包括治疗组876例,对照组869例,Meta分析结果表明:与单一西药疗法比较,膏方增强总有效率(TE) [OR = 3.64, 95% CI (2.36, 5.59), P Objective: To systematically and comprehensively investigate the clinical and related Meta-analyses of the adjuvant treatment of chronic obstructive pulmonary disease (COPD) with plaster formula. Methods: Randomized trials (RCTs) of plaster prescriptions for the treatment of COPD in the past five years were searched in Chinese and English databases at home and abroad, and risk of bias assessment and Meta-analysis were carried out using Revman 5.3 software. Result: A total of 22 articles and 1745 study subjects were included, including 876 cases in the treatment group and 869 cases in the control group, and the results of Meta-analysis showed that compared with a single Western drug therapy, the total effective rate (TE) was enhanced by the plaster formula [OR = 3.64, 95% CI (2.36, 5.59), P < 0.00001], increased the percentage of forced expiratory volume in 1 second to predicted value (FEV1%) [MD = 4.91, 95% CI (3.39, 6.43), P < 0.00001], reduced the number of acute exacerbations [MD = −0.34, 95% CI (−0.39, −0.28), P < 0.00001], and the adverse effects were mild and few. Conclusion: The addition of ointment in the treatment of COPD can significantly improve the overall physiological indexes of patients, including alleviating respiratory symptoms, and enhancing patients’ exercise ability and immunity, and has no obvious side effects, therefore, it is recommended to use ointment as an adjuvant drug for COPD, and ensure the safety and effectiveness of the drug through large-scale, high-precision, and multi-point monitoring experiments.
文摘目前,恶性肿瘤的发病率不断上升,且不断地年轻化,严重影响着人们的生命健康。化疗作为治疗恶性肿瘤的重要手段,通过化疗可以有效延长患者的生存周期,提高患者的生存质量。而骨髓抑制作为化疗常见的毒性反应之一,可导致化疗延期或中断,影响化疗的疗效。中医药作为我国传统的疾病治疗手段,有着价廉且有效的特点。本文主要对中医在化疗后骨髓抑制的研究现状作一综述。Currently, the incidence rate of malignant tumors is continuously rising and affecting younger age groups, seriously impacting people’s lives and health. As an important means to treat malignant tumors, chemotherapy can effectively prolong the life cycle of patients and improve the quality of life of patients. As one of the common toxic reactions of chemotherapy, myelosuppression can lead to the delay or interruption of chemotherapy and affect the efficacy of chemotherapy. As a traditional means of disease treatment in China, traditional Chinese medicine has the characteristics of being cheap and effective. This article mainly reviews the research status of myelosuppression after chemotherapy in traditional Chinese medicine.
文摘目的:利用网络药理学及分子对接探究菊花-夏枯草治疗高血压(hypertension)的作用机制。方法:利用TCMSP检测菊花及夏枯草的活性成分,利用GeneCards、OMIM等数据库获取与高血压病的有关靶点,运用Cytoscape软件建立“药物-活性成分-靶点”的调控网络,利用DAVID6.8进行GO和KEGG富集分析,最后使用Auto Dock Vna1.1.2软件对活性成分与关键靶点之间的分子对接。结论:共筛选出菊花及夏枯草共24个活性成分,高血压潜在治疗靶点157个,得到IL6、IL1B、AKT1、CASP3、TNF、TP53、EGFR、JUN、MMP9、MYC10个重要作用靶点;GO功能富集分析筛选出372条结果,KEGG通道富集包含肿瘤中的通道、流体切应力和动脉粥样硬化等信息通路。分子对接结果显示,主要活性成分与5个核心靶点(IL6、IL1B、AKT1、TNF、TP53)均有较好的亲和力。结论:菊花-夏枯草药对通过多成分、多靶点、多通道防治高血压,为中西医结合防治高血压提供更多的选择。
