火针治疗急性痛风性关节炎的研究进展

随着人们生活水平及饮食结构的变化,急性痛风性关节炎的发病率呈上升趋势,病情严重可能致畸、致残。西医治疗急性痛风性关节炎的副作用较大,且易复发。近年来,火针治疗急性痛风性关节炎取得较好的临床效果,越来越受到针灸学界的认可和重视。本文对火针治疗急性痛风性关节炎的机制研究、临床应用研究进展进行综述,为火针治疗急性痛风性关节炎提供依据。

电针治疗神经病理性疼痛机制研究进展

神经病理性疼痛是一种临床常见的顽固性慢性疼痛。电针可有效缓解神经病理性疼痛引起的不适,其作用机制可能涉及外周敏化、中枢敏化、下行抑制性调控,其中中枢敏化机制又可细分为脊髓背角神经元相关机制、胶质细胞活化抑制机制、信号通路相关机制以及突触可塑机制。但当前大多数研究的结论尚未得到明确证实,今后可借助基因推敲或相关抑制剂来开展进一步研究以验证作用机制。参考文献34篇。

基于现代数据挖掘技术分析中医外治法治疗膝骨关节炎的用药规律

目的:基于现代数据挖掘技术分析中医外治法治疗膝骨关节炎的药物应用规律,为临床治疗提供更多科学依据。方法:检索中国期刊全文数据库、万方数据知识服务平台、中文科技期刊数据库等近10年中医外治法治疗膝骨关节炎的文献,对所得处方的药物及其性味归经进行频数分析、聚类分析、关联规则分析及复杂网络分析。结果:纳入文献共涉及117个外用方,单个中药使用频率≥30的共15味,关联规则得到19组核心用药组合,聚类分析发现3个有效聚类群,复杂网络分析得到药物核心组合为红花、牛膝、川乌、透骨草、伸筋草。结论:中医外治法治疗膝骨关节炎用药主要以辛、苦、温为主,肝脾肾心同治,总治疗原则为祛风通络,活血止痛。

探讨艾灸在新型冠状病毒肺炎防疫中的应用价值

针对当前疫情拐点尚至的现状,探讨艾灸在疫情防控中的应用价值。基于古代文献记载溯源及现代医学研究文献整理归纳,认为艾灸在新型冠状病毒肺炎的灭菌、消毒和提高大众自身抵抗力等方面具有积极作用。并从治未病的三期核心思想辨证施灸,提出相应防治方案,以尽可能阻断病源、降低新增病例和新增医学隔离观察人员数、减少复发,充分发挥艾灸在新型冠状病毒肺炎防疫工作中的特色和优势。

腹针治疗膝骨性关节炎的研究进展

腹针及其复合疗法,包括中药口服、中药外用、针刺法、刺络法、推拿、红外线照射等在膝骨性关节炎的治疗上均有良好疗效,具有明显缓解关节疼痛、改善关节功能、提高患者日常生活能力、不良反应少等诸多优点。文章以腹针、膝骨关节炎作为关键词检索中国期刊全文数据库、万方知识服务平台、中文科技期刊数据库中近年来腹针治疗膝骨性关节炎的临床研究文献进行总结。腹针对膝骨性关节炎疼痛改善及关节功能影响的临床研究,旨在为临床采用腹针治疗膝骨性关节炎提供客观、科学的理论依据。

火针对比西药治疗痛风性关节炎血尿酸及关节功能影响Meta分析及试验序贯分析

Objective:To conduct the meta-analysis and trial sequential analysis(TSA) on clinical trials of fire needling therapy in treatment of gouty arthritis and review systematically the clinical therapeutic effect of fire needling therapy on gouty arthritis so as to provide the medical evidences of the extensive application of this therapy in treatment of gouty arthritis.Methods:The relevant clinical trials of fire needling therapy for treatment of gouty arthritis were searched from China National knowledge Infrastructure,Wanfang Data Knowledge Service Platform,Chinese Science and Technology Journal Database,American Medical Online,Dutch Medical Literature Database and International Evidence-Based Medical library.Using Review Manager 5.3 software,the quality of the included trials was assessed and meta-analysis was performed.With TSA v0.9 software,the trial sequential analysis was conduced on the appropriate outcomes.Results:A total of 10 trials were included with 775 patients involved.The analysis results showed that compared with the western medication,the total effective rate(RR=1.14’95%CI [1.09,1.20]),the curative rate(RR=1.59’95%CI [1.33,1.89]),the reduced VAS score(MD=-1.44’ 95%CI [-1.93,-0.951]) and the reduced incidence of adverse reaction(RR=0.27’ 95% CI [0.09,0.76]) of the fire needling therapy were different significantly(all P <0.05).Regarding the reduction of blood uric acid(MD=-40.47’ 95%CI [-80.21,-0.72]) and the score of symptoms and physical signs(MD=-1.38’95% CI [-3.71,0.95]),the effect of fire needling therapy was similar to that of western medication group(both P≥0.05).The trial sequential analysis suggested that the result was reliable,in which,the total effective rate of fire needling therapy was much higher than the western medication.But,it was potentially a false-positive finding,in which,fire needling therapy was much more advantageous at reducing blood uric acid as compared with the western medication.Conclusion:Based on the analytic results,it can be determined that fire needling therapy,as an effective approach to the treatment of gouty arthritis,has a certain advantage as compared with western medication.Given the low overall quality of trials,it still needs high-quality clinical trial to verify the findings of this study results.

电针对盆腔炎性疾病后遗症大鼠子宫组织环氧合酶-2和转化生长因子-β1表达的影响

目的:观察电针对盆腔炎性疾病后遗症(SPID)大鼠子宫组织环氧合酶-2(COX-2)、转化生长因子-β1(TGF-β1)表达的影响,探讨电针治疗SPID的作用机制。方法:雌性SD大鼠采用子宫菌液注射法复制SPID模型,随机分为电针组、模型组,每组6只,6只不造模设为空白组。选取双侧“三阴交”“子宫”,同侧接电行电针干预,20 min/次,1次/d,连续14 d。肉眼观察及评估宫腔狭窄、粘连情况,Western blot法检测子宫组织COX-2、TGF-β1蛋白表达水平。结果:与空白组比较,模型组宫腔狭窄、粘连评分显著升高(P<0.01),子宫组织COX-2、TGF-β1蛋白表达水平显著升高(P<0.01);与模型组比较,电针组宫腔狭窄、粘连评分显著降低(P<0.05),子宫组织COX-2、TGF-β1蛋白表达水平显著降低(P<0.01)。结论:电针干预可改善SPID大鼠子宫组织宫腔狭窄、粘连水平,其机制可能与电针调控COX-2、TGF-β1的表达有关。