Photodynamic therapy(PDT)is a treatment that uses light-sensitive drugs and a light source to destroy cancer cells.Methylene blue(MB)is an efficient photosensitizing agent that has been widely used in PDT.However,MB s...Photodynamic therapy(PDT)is a treatment that uses light-sensitive drugs and a light source to destroy cancer cells.Methylene blue(MB)is an efficient photosensitizing agent that has been widely used in PDT.However,MB suffers from the hypochromic effect that is caused by self-aggregation and DNA binding in vivo.It is also easily reduced to ineffective leucomethylene blue in the hypoxic environments surrounding solid tumors.In this work,we prepared MB carbon dots(MB-CDs)using MB as the carbon source.The MB-CDs not only inherit the PDT capabilities of MB,but also demonstrate good biocompatibility and low toxicity.Importantly,MB-CDs demonstrate excellent resistance to interference from reduction,aggregation,and DNA interactions.The MB-CDs exhibited satisfactory PDT activities both in vitro and in vivo.The tumor sizes were reduced to below 20%of their original volumes when irradiated by a 590-nm lightemitting diode source.展开更多
基金financially supported by the National Natural Science Foundation of China (NSFC, 21822804,21676047, 21421005, 21878039, and 21925802)NSFC-Liaoning United Fund (U1908202 and U1608222)
文摘Photodynamic therapy(PDT)is a treatment that uses light-sensitive drugs and a light source to destroy cancer cells.Methylene blue(MB)is an efficient photosensitizing agent that has been widely used in PDT.However,MB suffers from the hypochromic effect that is caused by self-aggregation and DNA binding in vivo.It is also easily reduced to ineffective leucomethylene blue in the hypoxic environments surrounding solid tumors.In this work,we prepared MB carbon dots(MB-CDs)using MB as the carbon source.The MB-CDs not only inherit the PDT capabilities of MB,but also demonstrate good biocompatibility and low toxicity.Importantly,MB-CDs demonstrate excellent resistance to interference from reduction,aggregation,and DNA interactions.The MB-CDs exhibited satisfactory PDT activities both in vitro and in vivo.The tumor sizes were reduced to below 20%of their original volumes when irradiated by a 590-nm lightemitting diode source.
