Objective:The authors used a meta-analytic technique to quantify the evidence of an association between maternal alcohol consumption during pregnancy and childhood acute leukemia(AL),which provided a basis for the pre...Objective:The authors used a meta-analytic technique to quantify the evidence of an association between maternal alcohol consumption during pregnancy and childhood acute leukemia(AL),which provided a basis for the prevention of childhood AL.Methods:Relevant literatures of maternal alcohol consumption during pregnancy were comprehensively searched and screened.Subgroup meta-analysis was conducted according to the type of leukemia.Results of research data of maternal alcohol consumption during pregnancy were tested for heterogeneity.Combined OR values and 95% CIs were statistically calculated with RevMan 4.2 software;Funnel plots were applied to conduct bias analysis for those included literatures.Results:Ten related literatures were included after data screening,4593 cases in AL group and 6157 cases in control group respectively.According to heterogeneity test result(χ2 = 16.26,P < 0.05),the combined OR values and 95% CI were calculated with random effects model,which were 1.02(0.92-1.14),Z = 0.41,P = 0.68 > 0.05,indicating that there was no significant difference between maternal alcohol consumption during pregnancy and the risk of childhood acute leukemia(AL).Subgroup analysis:for the association between maternal alcohol consumption during pregnancy and childhood acute lymphoblastic leukemia(ALL),the combined OR value and 95% CI were 0.92(0.84-1.00),Z = 1.92,P = 0.05,indicating that there was significant difference between two groups;for the association between maternal alcohol consumption during pregnancy and childhood acute non-lymphoblastic leukemia(ANLL),the combined OR values and 95% CI were 0.82(0.61-1.11),Z = 1.30,P = 0.19 > 0.05,indicating that there was no significant difference between two groups.Conclusion:Maternal alcohol consumption during pregnancy is a risk factor in childhood ALL,but not in childhood ANLL.展开更多
文摘Objective:The authors used a meta-analytic technique to quantify the evidence of an association between maternal alcohol consumption during pregnancy and childhood acute leukemia(AL),which provided a basis for the prevention of childhood AL.Methods:Relevant literatures of maternal alcohol consumption during pregnancy were comprehensively searched and screened.Subgroup meta-analysis was conducted according to the type of leukemia.Results of research data of maternal alcohol consumption during pregnancy were tested for heterogeneity.Combined OR values and 95% CIs were statistically calculated with RevMan 4.2 software;Funnel plots were applied to conduct bias analysis for those included literatures.Results:Ten related literatures were included after data screening,4593 cases in AL group and 6157 cases in control group respectively.According to heterogeneity test result(χ2 = 16.26,P < 0.05),the combined OR values and 95% CI were calculated with random effects model,which were 1.02(0.92-1.14),Z = 0.41,P = 0.68 > 0.05,indicating that there was no significant difference between maternal alcohol consumption during pregnancy and the risk of childhood acute leukemia(AL).Subgroup analysis:for the association between maternal alcohol consumption during pregnancy and childhood acute lymphoblastic leukemia(ALL),the combined OR value and 95% CI were 0.92(0.84-1.00),Z = 1.92,P = 0.05,indicating that there was significant difference between two groups;for the association between maternal alcohol consumption during pregnancy and childhood acute non-lymphoblastic leukemia(ANLL),the combined OR values and 95% CI were 0.82(0.61-1.11),Z = 1.30,P = 0.19 > 0.05,indicating that there was no significant difference between two groups.Conclusion:Maternal alcohol consumption during pregnancy is a risk factor in childhood ALL,but not in childhood ANLL.
