Background and Aims:Although hypovitaminosis D is common among patients with chronic liver disease(CLD),the data are inconsistent on its prevalence and its relationship with CLD.This study aimed to estimate the preval...Background and Aims:Although hypovitaminosis D is common among patients with chronic liver disease(CLD),the data are inconsistent on its prevalence and its relationship with CLD.This study aimed to estimate the prevalence of hypovitaminosis D among patients with CLD and to determine the relationship between hypovitaminosis D and severity of liver dysfunction,and calcium(Ca),phosphate(PO4)and parathyroid hormone(PTH)levels in CLD.Methods:The study included 236 CLD patients attending the Department of Hepatology,Rajiv Gandhi Government General Hospital(Chennai,India).Serum levels of 25-hydroxyvitamin D(25(OH)D),PTH,Ca,and PO4 were estimated.Severity of liver dysfunction was graded using the Child-Turcotte-Pugh(CTP)score.Results:The first report from our population showed that 162 of 236(68.6%)CLD patients had hypovitaminosis D(25(OH)D levels of<30 ng/mL),with higher frequency(124/162)76.5%among CTP B,C patients.Significant negative correlation(r=-0.288,p=0.0001)between 25(OH)D and CTP scores was noted in hypovitaminosis D conditions.Level of 25(OH)D was correlated negatively with PTH(r=-0.537,p=0.0001),positively with Ca(r=0.657,p=0.0001),and positively with PO4(r=0.477,p=0.0001)in sufficient vitamin D conditions.Conclusions:Hypovitaminosis D is associated with higher CTP scores and is strongly associated with dysregulation of the Ca-PTH-vitamin D axis in CLD.Timely measurement of vitamin D levels is essential,along with levels of PTH,Ca and PO4,to manage CLD patients.展开更多
文摘Background and Aims:Although hypovitaminosis D is common among patients with chronic liver disease(CLD),the data are inconsistent on its prevalence and its relationship with CLD.This study aimed to estimate the prevalence of hypovitaminosis D among patients with CLD and to determine the relationship between hypovitaminosis D and severity of liver dysfunction,and calcium(Ca),phosphate(PO4)and parathyroid hormone(PTH)levels in CLD.Methods:The study included 236 CLD patients attending the Department of Hepatology,Rajiv Gandhi Government General Hospital(Chennai,India).Serum levels of 25-hydroxyvitamin D(25(OH)D),PTH,Ca,and PO4 were estimated.Severity of liver dysfunction was graded using the Child-Turcotte-Pugh(CTP)score.Results:The first report from our population showed that 162 of 236(68.6%)CLD patients had hypovitaminosis D(25(OH)D levels of<30 ng/mL),with higher frequency(124/162)76.5%among CTP B,C patients.Significant negative correlation(r=-0.288,p=0.0001)between 25(OH)D and CTP scores was noted in hypovitaminosis D conditions.Level of 25(OH)D was correlated negatively with PTH(r=-0.537,p=0.0001),positively with Ca(r=0.657,p=0.0001),and positively with PO4(r=0.477,p=0.0001)in sufficient vitamin D conditions.Conclusions:Hypovitaminosis D is associated with higher CTP scores and is strongly associated with dysregulation of the Ca-PTH-vitamin D axis in CLD.Timely measurement of vitamin D levels is essential,along with levels of PTH,Ca and PO4,to manage CLD patients.
