There is evidence from in vitro and animal studies that endothelin is a major regulator of retinal blood flow. We set out to characterize the role of the endothelin-system in the blood flow control of the human retina...There is evidence from in vitro and animal studies that endothelin is a major regulator of retinal blood flow. We set out to characterize the role of the endothelin-system in the blood flow control of the human retina. Two studies in healthy subjects were performed. The study design was randomized, placebo-con-展开更多
Purpose: There is evidence from a variety of animal studies that the adenosine system plays a role in the control of intraocular pressure (IOP) and ocular blood flow. However, human data on the effect of adenosine on ...Purpose: There is evidence from a variety of animal studies that the adenosine system plays a role in the control of intraocular pressure (IOP) and ocular blood flow. However, human data on the effect of adenosine on IOP, choroidal and optic nerve blood flow are lacking. Methods: We investigated the effect of stepwise increasing doses of adenosine (10, 20, 40μg/kg/min, 30 min-展开更多
Background: To investigate the effects of oral nimodipine on ocular hemodynamic parameters and color contrast sensitivity in patients with normal tension glaucoma (NTG). Methods: The study was performed in 14 consecut...Background: To investigate the effects of oral nimodipine on ocular hemodynamic parameters and color contrast sensitivity in patients with normal tension glaucoma (NTG). Methods: The study was performed in 14 consecutive NTG patients in a randomized placebo controlled double-masked cross-over design. The effects or oral nimodipine (60 mg) or placebo on ocular and systemic hemodynamic parameters and color contrast展开更多
文摘There is evidence from in vitro and animal studies that endothelin is a major regulator of retinal blood flow. We set out to characterize the role of the endothelin-system in the blood flow control of the human retina. Two studies in healthy subjects were performed. The study design was randomized, placebo-con-
文摘Purpose: There is evidence from a variety of animal studies that the adenosine system plays a role in the control of intraocular pressure (IOP) and ocular blood flow. However, human data on the effect of adenosine on IOP, choroidal and optic nerve blood flow are lacking. Methods: We investigated the effect of stepwise increasing doses of adenosine (10, 20, 40μg/kg/min, 30 min-
文摘Background: To investigate the effects of oral nimodipine on ocular hemodynamic parameters and color contrast sensitivity in patients with normal tension glaucoma (NTG). Methods: The study was performed in 14 consecutive NTG patients in a randomized placebo controlled double-masked cross-over design. The effects or oral nimodipine (60 mg) or placebo on ocular and systemic hemodynamic parameters and color contrast
