Objective: Cyclo-oxygenase-2 seems to be involved at various steps in the processes of tumor progression. The abstract Objective of this study was to examine the relationship between cyclo- oxygenase- 2 expression and...Objective: Cyclo-oxygenase-2 seems to be involved at various steps in the processes of tumor progression. The abstract Objective of this study was to examine the relationship between cyclo- oxygenase- 2 expression and tumor proliferation, apoptosis and angiogenesis in patients with advanced stage high- grade ovarian carcinoma. Study design: Specimens from 118 patients with high- grade and advanced stage (III, IV) serous ovarian carcinoma were evaluated by immunohistochemistry for cyclo- oxygenase- 2, Ki- 67, vascular endothelial growth factor, and bcl- 2 expression. Tumor microvessel density was assessed with CD34 immunostaining. We investigated the relationships between cyclo- oxygenase- 2 expression and clinicopathologic characteristics, tumor angiogenesis (tumor microvessel density and vascular endothelial growth factor expression), and tumor proliferation and apoptosis. The effect of cyclo- oxygenase- 2 expression on patient survival was determined. Results: There was a significant positive correlation between cyclo- oxygenase- 2 expression in tumor cells and markers of tumor proliferation and angiogenesis. In univariate survival analysis, high cyclo- oxygenase- 2 and high Ki- 67 expression showed a significant impact of on patient survival (P <. 001). In multivariate regression analysis, only Ki- 67 expression retained its significance as an independent poor prognostic factor (death hazard ratio, 2.0; 95% CI, 1.2- 3.3;P <. 001). Conclusion: Expression of cyclo- oxygenase- 2 correlates with tumor proliferation and tumor angiogenesis but not with apoptotic markers (bcl- 2 expression) in high- grade, advanced- stage serous ovarian carcinoma. Catastrophizing labor pain compromises later maternity adjustments Ferber S.G./Granot M./Zimmer E.Z. [Dr. S.G. Ferber, Fac. Social Welf. and Hlth. Studs., University of Haifa, Mount Carmel, Haifa 31905, Israel] Abstract Objective: The purpose of this study was to evaluate the impact of labor pain intensity and labor pain catastrophizing on maternity blues and postpartum social functioning. Study design: Pain intensity and pain catastrophizing were assessed in 89 women in active labor before the administration of analgesia. Both these measures were assessed again retrospectively 2 days after delivery in 82 women who had a spontaneous vaginal delivery. Women also filled out the Edinburgh Postnatal Depression Scale. Six weeks later women completed the social functioning domain of the short form SF36 health survey. Results: Pain catastrophizing during labor significantly predicted both maternity blues (P =. 001) and postpartum social functioning (P =. 001) when being controlled for maternal age and education, parity, type of analgesia, and labor pain intensity. Low level of education and younger age also contributed to the prediction of maternity blues and social functioning. Conclusion: Labor pain catastrophizing rather than labor pain intensity predicts postpartum maternal adjustments.展开更多
文摘Objective: Cyclo-oxygenase-2 seems to be involved at various steps in the processes of tumor progression. The abstract Objective of this study was to examine the relationship between cyclo- oxygenase- 2 expression and tumor proliferation, apoptosis and angiogenesis in patients with advanced stage high- grade ovarian carcinoma. Study design: Specimens from 118 patients with high- grade and advanced stage (III, IV) serous ovarian carcinoma were evaluated by immunohistochemistry for cyclo- oxygenase- 2, Ki- 67, vascular endothelial growth factor, and bcl- 2 expression. Tumor microvessel density was assessed with CD34 immunostaining. We investigated the relationships between cyclo- oxygenase- 2 expression and clinicopathologic characteristics, tumor angiogenesis (tumor microvessel density and vascular endothelial growth factor expression), and tumor proliferation and apoptosis. The effect of cyclo- oxygenase- 2 expression on patient survival was determined. Results: There was a significant positive correlation between cyclo- oxygenase- 2 expression in tumor cells and markers of tumor proliferation and angiogenesis. In univariate survival analysis, high cyclo- oxygenase- 2 and high Ki- 67 expression showed a significant impact of on patient survival (P <. 001). In multivariate regression analysis, only Ki- 67 expression retained its significance as an independent poor prognostic factor (death hazard ratio, 2.0; 95% CI, 1.2- 3.3;P <. 001). Conclusion: Expression of cyclo- oxygenase- 2 correlates with tumor proliferation and tumor angiogenesis but not with apoptotic markers (bcl- 2 expression) in high- grade, advanced- stage serous ovarian carcinoma. Catastrophizing labor pain compromises later maternity adjustments Ferber S.G./Granot M./Zimmer E.Z. [Dr. S.G. Ferber, Fac. Social Welf. and Hlth. Studs., University of Haifa, Mount Carmel, Haifa 31905, Israel] Abstract Objective: The purpose of this study was to evaluate the impact of labor pain intensity and labor pain catastrophizing on maternity blues and postpartum social functioning. Study design: Pain intensity and pain catastrophizing were assessed in 89 women in active labor before the administration of analgesia. Both these measures were assessed again retrospectively 2 days after delivery in 82 women who had a spontaneous vaginal delivery. Women also filled out the Edinburgh Postnatal Depression Scale. Six weeks later women completed the social functioning domain of the short form SF36 health survey. Results: Pain catastrophizing during labor significantly predicted both maternity blues (P =. 001) and postpartum social functioning (P =. 001) when being controlled for maternal age and education, parity, type of analgesia, and labor pain intensity. Low level of education and younger age also contributed to the prediction of maternity blues and social functioning. Conclusion: Labor pain catastrophizing rather than labor pain intensity predicts postpartum maternal adjustments.
