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A T-Cell Model for the Biological Role of Selenium-Dependent Glutathione Peroxidase
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作者 alan m. diamond YASUSHI KATAOKA +3 位作者 JUDITH mURRAY DUAN CHENGYING THOmAS m. FOLKST,AND PAUL. A. SANDSTROm(Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637 USA Retrovirus Disease Branch, Division of Viral and Rickettsial 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 1997年第2期246-252,共7页
The cytosolic form of selenium-dependent glutathione peroxidase detoxifies both hydrogen and lipid peroxides and therefore represents a major component of the cellular anti-oxidant defenses. In order to study the biol... The cytosolic form of selenium-dependent glutathione peroxidase detoxifies both hydrogen and lipid peroxides and therefore represents a major component of the cellular anti-oxidant defenses. In order to study the biological role of this enzyme, we generated an expression construct in a retroviral vector, which when introduced into immortalized human T-cells, resulted in significant increases in the activity of this important enzyme. This effect is stable over extended maintenance in culture. The anti-oxidant defenses in these same cells are also shown to be attenuated hy chemically reducing cellular glutathione levels. Collectively, the abllity to both increase and decrease the anti-oxidant defenses in human T cells results in a useful model system for the study of oxidative stress and signaling in this cell type 展开更多
关键词 RES cell A T-Cell Model for the Biological Role of Selenium-Dependent Glutathione Peroxidase HIV AIDS
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