Nursing effect of narrative nursing intervention on postoperative patients with severe lung cancer

BACKGROUND Lung cancer is a common disease with high mortality,and psychological support is very important in the diagnosis and treatment of postoperative patients with cancer pain.AIM To explore the application effect of the narrative nursing method in postoperative lung cancer patients in the intensive care unit.METHODS A total of 120 patients diagnosed with lung cancer and experiencing cancer-related pain were randomly allocated into two groups:an observation group and a control group,each consisting of 60 cases.The control group was given routine analgesic and psychological care,while the research group applied the five-step narrative nursing method based on routine care,comparing the visual analogue scale scores,sleep status,anxiety and depression status,and quality of life of the two groups of patients before and after the intervention.RESULTS The pain scores,anxiety scores,and depression scores of the study group were lower than those of the control group after the intervention using the narrative nursing method,and the difference was statistically significant(P<0.05).CONCLUSION Using narrative nursing methods to intervene in patients with lung cancer combined with cancerous pain can help patients to correctly recognize their disease,adjust their mentality,establish confidence,alleviate patients'subjective pain feelings,and improve their adverse emotions.

Sciadopitysin exerts anticancer effects on HepG2 hepatocellular carcinoma cells by regulating reactive oxygen species-mediated signaling pathways

Objectives:Sciadopitysin(SP)is aflavonoid in Ginkgo biloba that exhibits various pharmacological activities.This study aimed to investigate its antitumor effects and the underlying molecular mechanism of SP in hepatocellular carcinoma(HCC)cells.Methods:Network pharmacology was used for target prediction analysis.Cell Counting Kit-8(CCK-8)assay was used to test the cell viability.Flow cytometry was used to test the cell cycle distribution,apoptosis status,and reactive oxygen species(ROS)levels.Transwell and wound-healing assay was used to test the migration effect of SP on HepG2 cells.Western Blot assay was used to test the expression levels of proteins.Results:Network pharmacology analysis results showed that the mitogen-activated protein kinase(MAPK)and other signaling pathways are involved in the SP anti-HCC biological process.CCK-8 assay results demonstrated that SP showed an obvious killing effect on three types of HCC cells and low cytotoxic effect on normal cells.Western Blot andflow cytometry results showed that SP regulated MAPK/signal transducer and activator of transcription 3(STAT3)/nuclear factor kappa-B(NF-κB)signaling pathway to induce mitochondrion-dependent apoptosis in HepG2 cells.Additionally,SP can arrest the G0/G1 phase cell cycle via the protein kinase B(AKT)/p21/p27/cyclin-dependent kinase(CDK)/Cyclin signaling pathway.Wound healing and transwell assays showed that SP inhibited cell motility and invasion through the AKT/glycogen synthase kinase3β(GSK-3β)/vimentin/β-catenin signaling pathway.Conclusion:Thesefindings demonstrated that SP induced mitochondrion-dependent apoptosis,arrested cell cycle in the G0/G1 phase,and inhibited cell migration by regulating the ROS-mediated signaling pathway in HepG2 cells.Thus,SP could serve as a therapeutic agent for the treatment of human HCC.

类器官模型在结直肠癌研究中的应用

类器官是近年来逐渐兴起的一种新型研究模型,在疾病发展、药物筛选、新药研发、个性化医疗等领域应用前景广阔。近年来,结直肠癌类器官模型已较为成熟,本文对结直肠癌研究中的常见模型及其类器官模型的构建与应用现状作一综述。

Moxibustion combined with acupuncture increases tight junction protein expression in Crohn's disease patients

AIM:To investigate the effect of herb-partitioned moxibustion combined with acupuncture on the expression of intestinal epithelial tight junction(TJ) proteins.METHODS:Sixty patients diagnosed with mild to moderate Crohn’s disease(CD)were allocated into the herb-partitioned moxibustion combined with acupuncture(HMA)group(n=30)or the mesalazine(MESA)group(n=30)using a parallel control method.There were 2 sets of acupoints used alternately for HMA treatment.The following points were included in Set A:ST25(Tianshu),RN6(Qihai),and RN9(Shuifen)for herb-partitioned moxibustion and ST36(Zusanli),ST37(Shangjuxu),LI11(Quchi),and LI4(Hegu)for acupuncture.The points for Set B included BL23(Shenshu)and BL25(Dachangshu)for herb-partitioned moxibustion and EX-B2 of T6-T1(Jiajixue)fo r acupuncture.The patients received the same treatment6 times a week for 12 consecutive weeks.The MESA group received 1 g of mesalazine enteric coated tablets4 times daily for 12 consecutive weeks.Intestinaltissues were stained and examined to compare the morphological and ultrastructural changes before and after the treatment session.Immunohistochemistry and in situ hybridization assays were used to detect the expression of intestinal epithelial TJ proteins zonula occludens-1(ZO-1),occludin,and claudin-1.The m RNA levels were also evaluated.RESULTS:After the treatment,both herb-partitioned moxibustion combined with acupuncture and mesalazine improved intestinal morphology and ultrastructure of CD patients;the patients treated with HMA showed better improvement.HMA significantly increased the expression of ZO-1(P=0.000),occludin(P=0.021),and claudin-1(P=0.016).MESA significantly increased the expression of ZO-1(P=0.016)and occludin(P=0.026).However,there was no significant increase in the expression of claudin-1(P=0.935).There was no statistically significant difference between the two groups for the expression of occludin and claudin-1(P>0.05).The HMA group showed a significant improvement in ZO-1 expression compared to the MESA group(2333.34±352.51 vs 2160.38±307.08,P=0.047).HMA significantly increased the expression of ZO-1 m RNA(P=0.000),occludin m RNA(P=0.017),and claudin-1 m RNA(P=0.017).MESA significantly increased the expression of ZO-1 m RNA(P=0.000),occludin m RNA(P=0.042),and claudin-1 m RNA(P=0.041).There was no statistically significant difference between the two groups in the expression of occludin and claudin-1 m RNA(P>0.05).However,the HMA group showed a significant improvement in ZO-1 m RNA expression compared with the MESA group(2378.17±308.77 vs 2200.56±281.88,P=0.023).CONCLUSION:HMA can repair intestinal epithelial barrier lesions and relieve inflammation by upregulating the expression of TJ proteins and their m RNAs.

Crust–mantle interaction recorded by Early Cretaceous volcanic rocks within the southern margin of the North China Craton

This study presents new geochronological and geochemical data for Early Cretaceous volcanic rocks in the southern margin of the North China Craton(NCC),to discuss the crust–mantle interaction.The studied rocks include pyroxene andesites from Daying Formation,hornblende andesites and andesites from Jiudian Formation,and rhyolites from a hitherto unnamed Formation.These rocks formed in Early Cretaceous(138–120 Ma),with enrichment in light rare earth elements(REE),depletion in heavy REE and arc-like trace elements characteristics.Pyroxene andesites show low SiO_(2) contents and enriched Sr–Nd–Pb–Hf isotopic compositions,with orthopyroxene phenocryst and Paleoproterozoic(2320–1829 Ma)inherited zircons,suggesting that they originated from lithospheric mantle after metasomatism with NCC lower crustal materials.Hornblende andesites have low SiO_(2) contents and high Mg#(Mg#=100 Mg/(Mg+Fe^(2+)))values,indicating a lithospheric-mantle origin.Considering the distinct wholerock Sr isotopic compositions we divide them into two groups.Among them,the low(^(87)Sr/^(86)Sr)iandesites possess amount inherited Neoarchean to Neoproterozoic(2548–845 Ma)zircons,indicating the origin of lithospheric mantle with addition of Yangtze Craton(YC)and NCC materials.In comparison,the high(^(87)Sr/^(86)Sr)iandesites,with abundant Neoarchean–Paleozoic inherited zircons(3499–261 Ma),are formed by partial melting of lithospheric mantle with incorporation of NCC supracrustal rocks and YC materials.Rhyolites have extremely high SiO_(2)(77.63–82.52 wt.%)and low total Fe_(2)O_(3),Cr,Ni contents and Mg#values,combined with ancient inherited zircon ages(2316 and 2251 Ma),suggesting an origin of NCC lower continental crust.Considering the presence of resorption texture of quartz phenocryst,we propose a petrogenetic model of’crystal mushes’for rhyolites prior to their eruption.These constraints record the intense crust–mantle interaction in the southern margin of the NCC.Given the regional data and spatial distribution of Early Cretaceous rocks within NCC,we believe that the formation of these rocks is related to the contemporaneous far-field effect of the Paleo-Pacific Plate.

利用轨道转移力矩实现室温范德华磁存储

具有非易失性的磁阻式随机存取存储器(MRAM)促进了诸如存内计算、神经形态计算和随机计算等在内的新兴应用.二维范德华异质结具有原子级平滑的界面和高度可调的物理性质,为MRAM的发展提供了新的技术路线.本文报道了基于WTe_2/Fe_(3)GaTe_(2)/BN/Fe_(3)GaTe_(2)异质结构的全二维范德华磁存储器件,实现了室温下数据读取和写入的全电学调控.其数据读取基于由Fe_(3)GaTe_(2)/BN/Fe_(3)GaTe_(2)构筑的磁隧道结,而数据写入是通过WTe_(2)中电流诱导的轨道磁矩极化来实现的.该磁矩对近邻的磁性层Fe_(3)GaTe_(2)施加力矩作用,称为轨道转移力矩(OTT)效应.与传统的自旋转移力矩和自旋轨道力矩相比,OTT效应充分利用了WTe_2中面外取向的轨道磁矩,通过施加界面电流实现无外磁场辅助的垂直磁化翻转.该研究结果表明,基于轨道转移力矩的OTT-MRAM极有希望作为低功耗、高性能的存储器件应用.

Controllable synthesis and tunable photocatalytic activity of TiO2 nanowires via alcohol-thermal method

Titania nanowires(TiO2-NW)with tunable aspect ratios and morphologies were directly synthesized using a simple alcohol-thermal technique.Specifically,ethanol and acetic acid were used as solvents and lithium ion was used as the capping agent to promote the conversion of titanium butoxide into TiO2-NW.The morphologies and crystal phases of TiO2-NW were determined by the molar ratio of solvents and the content(mol%)of lithium ion.The band gap of TiO2-NW with pure anatase phase is slightly bigger than that of TiO2-NW with a mixture of anatase and rutile phases.All TiO2-NW could achieve effective decolorization of methyl blue(the decolorization rate is over 95%)after 35-min ultraviolet(UV)irradiation.

Topological nature of higher-order hinge states revealed by spin transport

One-dimensional(1D)gapless hinge states are predicated in the three-dimensional(3D)higher-order topological insulators and topological semimetals,because of the higher-order bulk-boundary correspondence.Nevertheless,the topologically protected property of the hinge states is still not demonstrated so far,because it is not accessible by conventional methods,such as spectroscopy experiments and quantum oscillations.Here,we reveal the topological nature of hinge states in the higher-order topological semimetal Cd;As;nanoplate through spin potentiometric measurements.The results of current induced spin polarization indicate that the spin-momentum locking of the higher-order hinge state is similar to that of the quantum spin Hall state,showing the helical characteristics.The spin-polarized hinge states are robust up to room temperature and can nonlocally diffuse a long distance larger than 5μm,further indicating their immunity protected by topology.Our work deepens the understanding of transport properties of the higher-order topological materials and should be valuable for future electronic and spintronic applications.

Genome-wide DNA methylation patterns in monocytes derived from patients with primary Sjogren syndrome

Background:Epigenetics,especially DNA methylation,plays an important role in the pathogenesis of primary Sjogren syndrome(pSS).Our study aimed to reveal the role of DNA methylation in peripheral monocytes of pSS patients.Methods:A total of 11 pSS patients and five age-matched healthy controls(HCs)were included in this study.Monocytes were isolated from peripheral blood mononuclear cells using magnetic microbeads.DNA methylation profiles were generated using Human Methylation 850K BeadChips.Results:In monocytes from pSS patients,we identified 2819 differentially methylated positions(DMPs),comprising 1977 hypomethylated-and 842 hypermethylated-DMPs,corresponding to 1313 unique genes when compared with HCs.IFI44L,MX1,PAARP9,and IFITM1,which influence the interferon(IFN)signaling pathway,were among the genes hypomethylated in pSS.Functional analysis of genes with a minimum of two DMPs showed involvement in antigen binding,transcriptional regulation,cell adhesion,IFN-g pathway,type I IFN pathway,antigen presentation,Epstein-Barr virus infection,human T-lymphotropic virus type 1 virus infection,and metabolic disease-related pathways.In addition,patients with higher serum IgG levels exhibited enrichment in Notch signaling and metabolic-related pathways.Upon comparing monocytes with salivary gland epithelial cells,an important overlap was observed in the cell cycle,cell senescence,and interleukin-17 signaling pathways.The differentially methylated genes were more enriched in the ribosome-and AMP-activated protein kinase signaling pathway in anti-Ro/SSA and anti-La/SSB autoantibodies double-positive patients.Conclusion:Genome-wide DNA methylation profiling revealed significant differences in DNA methylation in monocytes isolated from patients with pSS.