Aggregate is a worldwide raw material used for various construction purposes which are obtained from geological material through drilling, blasting, mining, and river derived. This study has been focused on river Panj...Aggregate is a worldwide raw material used for various construction purposes which are obtained from geological material through drilling, blasting, mining, and river derived. This study has been focused on river Panjkora and Kunai-derived aggregates which are natural sources of aggregate used for various construction purposes in Dir (Lower). Field observation and detailed petrographic studies of representative samples reveal that rivers Panjkora and Kunai pass from different lithological units of granite, gabbroic, and amphibolite. Petrographically, the granitic rocks of the study area are consisting of alkali feldspar, quartz, and plagioclase feldspar. Minor accessory minerals in granite were hornblende, biotite, epidote, rutile, zircon, and ore minerals. The gabbroic rocks are consisting of pyroxene, plagioclase, and minor to accessory minerals including biotite, sphene, rutile, epidote, and ore minerals. The main mineral phases in amphibolites are hornblende, plagioclase, and a minor amount of quartz, sphene, and ore minerals. Gneissose fabric has developed in amphibolite refers to its banded nature. The minor mineral phases of amphibolite include epidote, ore minerals, and garnet. The feldspar alteration in granite is in the form of sericitization and normal zoning. The physical properties of river Panjkora and Kunai float i.e., water absorption, specific gravity, fine modulus, loss Angeles and soundness were within the range. Both petrographic and geotechnical properties suggested that these aggregates are suitable to be used as coarse aggregate in concrete. These must be present in the recommendation section at the end.展开更多
Proteintyrosine phosphatase 1B(PTP1B)inhibitionis consideredas a potentialtherapeuticfor the treatmentof cancer,type2 diabetes,andobesity.Inour presentwork,weinvestigatedtheanti-diabeticpotentialof8-hydroxydiospyrin(8...Proteintyrosine phosphatase 1B(PTP1B)inhibitionis consideredas a potentialtherapeuticfor the treatmentof cancer,type2 diabetes,andobesity.Inour presentwork,weinvestigatedtheanti-diabeticpotentialof8-hydroxydiospyrin(8-HDN)from D.lotus against the PTP1B enzyme.It showed significant inhibitory activity of PTP1B with an IC 50 value of 18.37±0.02μM.A detailed molecular docking study was carried out to analyze the binding orientation,binding energy,and mechanism of inhibition.A comparative investigation of 8-HDN in the catalytic,as well as the allosteric site of PTP1B,was performed.Binding energy data showed that compound 8-HDN is more selective for the allosteric site and hence avoids the problems associated with catalytic site inhibition.The inhibition mechanism of 8-HDN can be further investigated as an active lead compound against PTP1B by using in vitro and in vivo models.展开更多
In this paper we define N-fuzzy filters,N-fuzzy bi-ideal subsets and N-fuzzy bi-filters of ordered semigroups and characterize ordered semigroups in terms of N-fuzzy filters,N-fuzzy bi-ideal subsets and N-fuzzy bi-fil...In this paper we define N-fuzzy filters,N-fuzzy bi-ideal subsets and N-fuzzy bi-filters of ordered semigroups and characterize ordered semigroups in terms of N-fuzzy filters,N-fuzzy bi-ideal subsets and N-fuzzy bi-filters.We establish relationship of N-fuzzy filters and prime N-fuzzy ideals of ordered semigroups. Also we discuss the relationship of N-fuzzy bi-filters and prime N-fuzzy bi-ideal subsets of ordered semigroups.展开更多
In this paper,we define intuitionistic fuzzy generalized bi-ideals in ordered semigroups and characterize regular and left weakly regular ordered semigroups in terms of intuitionistic fuzzy generalized bi-ideals.
文摘Aggregate is a worldwide raw material used for various construction purposes which are obtained from geological material through drilling, blasting, mining, and river derived. This study has been focused on river Panjkora and Kunai-derived aggregates which are natural sources of aggregate used for various construction purposes in Dir (Lower). Field observation and detailed petrographic studies of representative samples reveal that rivers Panjkora and Kunai pass from different lithological units of granite, gabbroic, and amphibolite. Petrographically, the granitic rocks of the study area are consisting of alkali feldspar, quartz, and plagioclase feldspar. Minor accessory minerals in granite were hornblende, biotite, epidote, rutile, zircon, and ore minerals. The gabbroic rocks are consisting of pyroxene, plagioclase, and minor to accessory minerals including biotite, sphene, rutile, epidote, and ore minerals. The main mineral phases in amphibolites are hornblende, plagioclase, and a minor amount of quartz, sphene, and ore minerals. Gneissose fabric has developed in amphibolite refers to its banded nature. The minor mineral phases of amphibolite include epidote, ore minerals, and garnet. The feldspar alteration in granite is in the form of sericitization and normal zoning. The physical properties of river Panjkora and Kunai float i.e., water absorption, specific gravity, fine modulus, loss Angeles and soundness were within the range. Both petrographic and geotechnical properties suggested that these aggregates are suitable to be used as coarse aggregate in concrete. These must be present in the recommendation section at the end.
基金funded by Higher Education commission,Pakistan(HEC),Grant No.NRPU649.
文摘Proteintyrosine phosphatase 1B(PTP1B)inhibitionis consideredas a potentialtherapeuticfor the treatmentof cancer,type2 diabetes,andobesity.Inour presentwork,weinvestigatedtheanti-diabeticpotentialof8-hydroxydiospyrin(8-HDN)from D.lotus against the PTP1B enzyme.It showed significant inhibitory activity of PTP1B with an IC 50 value of 18.37±0.02μM.A detailed molecular docking study was carried out to analyze the binding orientation,binding energy,and mechanism of inhibition.A comparative investigation of 8-HDN in the catalytic,as well as the allosteric site of PTP1B,was performed.Binding energy data showed that compound 8-HDN is more selective for the allosteric site and hence avoids the problems associated with catalytic site inhibition.The inhibition mechanism of 8-HDN can be further investigated as an active lead compound against PTP1B by using in vitro and in vivo models.
基金supported by the Higher Education Commission of Pakistan under Grant No.I-8/HEC/HRD/2007/182
文摘In this paper we define N-fuzzy filters,N-fuzzy bi-ideal subsets and N-fuzzy bi-filters of ordered semigroups and characterize ordered semigroups in terms of N-fuzzy filters,N-fuzzy bi-ideal subsets and N-fuzzy bi-filters.We establish relationship of N-fuzzy filters and prime N-fuzzy ideals of ordered semigroups. Also we discuss the relationship of N-fuzzy bi-filters and prime N-fuzzy bi-ideal subsets of ordered semigroups.
文摘In this paper,we define intuitionistic fuzzy generalized bi-ideals in ordered semigroups and characterize regular and left weakly regular ordered semigroups in terms of intuitionistic fuzzy generalized bi-ideals.
